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›› 2005, Vol. 5 ›› Issue (1): 49-53.

• 过程与工艺 • 上一篇    下一篇

一种新型胺基树脂的制备

朱建星,魏荣卿,刘晓宁,卞国建,欧阳平凯   

  1. 南京工业大学制药与生命科学学院
  • 出版日期:2005-01-20 发布日期:2005-01-20

Preparation of a New Amino Resin by Mannich Reaction

ZHU Jian-xing,WEI Rong-qing,LIU Xiao-ning,BIAN Guo-jian,OUYANG Ping-kai   

  1. College of Life Science and Pharmaceutical Engineering, Nanjing University of Technology
  • Online:2005-01-20 Published:2005-01-20

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摘要： 以乙酰化聚苯乙烯微球为原料经Mannich反应制备了一种新型胺基树脂，该树脂可替代氯甲基树脂制备的阴离子交换树脂及酶固定化胺基载体，因此，避免了氯甲基树脂生产中使用氯甲醚等致癌物质及多取代、二次交联等副反应的问题. 讨论了反应温度和时间、物料比、加料方式、介质中的水量等因素的影响. 最佳反应条件为无水乙醇介质，胺:醛:盐酸:乙酰基(摩尔比) 10:10:3.3:1，反应温度100℃，反应时间12 h，制备的胺基树脂氮含量为13.7 mmol/g. 机理研究显示乙酰基发生 多取代反应.

关键词: 乙酰化聚苯乙烯, Mannich反应, 胺基树脂, 阴离子交换树脂, 酶固定化载

Abstract: A new amino resin was prepared from acetylated polystyrene micro-beads, formaldehyde and tetraethylene pentamine by the Mannich reaction, which can be substituted for anion-exchange resin prepared from chloromethyl polystyrene resin and immobilization support of enzyme. Influencing factors such as molar ratio of materials, reaction temperature and time, feeding methods as well as water in ethanol medium were discussed. The optimum experimental conditions were gained as follows: tetraethlene pentamine:formaldehyde: hydrochloride:acetyl(mole ratio) 10:10:3.3:1, reaction temperature 100℃, and reaction time 12 h. Under these experimental conditions, the product containing 13.7 mmol/g of nitrogen was obtained. The multi-substitution reaction of acetyl groups was also discussed.

Key words: acetylated polystyrene, mannich reaction, amino resin, anion-exchange resin, immobilization support of enzyme