关键词: 乳酸, 微生物生产, 代谢工程

Abstract: Metabolic engineering can regulate the metabolic networks of the microbial cells. It plays an important role in selecting microorganisms and optimizing the process to enhance metabolites production. The progress of the metabolic engineering research in lactic acid production was reviewed. Metabolic pathways in homo-fermentation and hetero-fermentation for lactic acid production were compared. The metabolic model of lactic acid bacteria, the application of lactate dehydrogenase and the production of lactic acid with Rhizopus oryzae fermentation were summarized. The gene regulatory knockout of ethanol metabolic pathway for improving the lactic acid production was introduced. The influences of bioinformatics and stress response on the metabolism of lactic acid were discussed. And the trends in microbial production of lactic acid were also predicted.

Key words: lactic acid, microbial production, metabolic engineering