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›› 2013, Vol. 13 ›› Issue (3): 466-473.

• 生化工程专栏 • 上一篇    下一篇

快速膜乳化法制备尺寸均一PELA多孔微球及其孔径调控

张慧霞 韦祎 王玉霞 阮燕烨 马光辉   

  1. 沈阳农业大学 中国科学院过程工程研究所生化工程国家重点实验室 中国科学院过程工程研究所生化工程国家重点实验室 沈阳农业大学 中国科学院过程工程研究所生化工程国家重点实验室
  • 收稿日期:2013-04-19 修回日期:2013-04-27 出版日期:2013-06-20 发布日期:2013-06-20
  • 通讯作者: 张慧霞

Preparation of Uniform-sized Porous PELA Microspheres and Their Pore Size Control

ZHANG Hui-xia WEI Yi WANG Yu-xia RUAN Yan-ye MA Guang-hui   

  1. Shenyang Agriculture University State Key Lab of Biochemical Engineering, Institute of Process Engineering, CAS State Key Lab of Biochemical Engineering, Institute of Process Engineering, CAS Shenyang Agriculture University State Key Lab. Biochem. Eng., Inst. Process Eng., Chinese Academy of Sciences
  • Received:2013-04-19 Revised:2013-04-27 Online:2013-06-20 Published:2013-06-20
  • Contact: ZHANG Hui-xia

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摘要： 采用快速膜乳化法，以二氯甲烷为油相，通过溶剂挥发制孔，在室温下制备了一系列聚乙二醇-聚乳酸共聚物(PELA)多孔微球. 结果表明，优化的制备条件为：搅拌速度250 r/min、油相中PELA浓度50 g/L、水/二氯甲烷/PVA水溶液体积比1:2.5:25及mPEG:PLA分子量比1:14，在该条件下可制备粒径均一、尺寸可控的PELA多孔微球，且孔径较大，孔径最大为15.0 nm，属介孔材料，可用于蛋白多肽类药物的吸附.

关键词: 聚乙二醇-聚乳酸, 多孔微球, 快速膜乳化, 溶剂挥发, 载药微球

Abstract: Uniform-sized poly(ethylene glycol-co-lactide) (PELA) microspheres were prepared by a combined method of solvent evaporation and Shirasu porous glass membrane emulsification at room temperature with dichloromethane as oil phase. The results show that the suitable conditions to prepare the larger pore size and uniform-sized PELA microspheres are: stirring speed 250 r/min, PELA concentration in oil phase 50 g/L, volume ratio of water/dichloromethane/PVA solution 1:2.5:25, and molecular weight ratio of monomethoxy-poly(ethylene glycol) to poly(lactide acid) 1:14. The average pore size of final microspheres is 15 nm, belonging to the mesoporous material, which can be used as drug carrier to adsorb protein or peptide drugs.

Key words: poly(ethylene glycol-co-lactide), porous microsphere, premix membrane emulsification, solvent evaporation, drug carrier

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