氨基葡萄糖-镝配合物的合成和抗羟自由基活性

›› 2008, Vol. 8 ›› Issue (5): 967-971.

氨基葡萄糖-镝配合物的合成和抗羟自由基活性

任群翔翟玉春葛欣秦岩

收稿日期:2008-05-08 修回日期:2008-07-22 出版日期:2008-10-20 发布日期:2008-10-20

Synthesis and Anti-hydroxyl Free Radical Activity of Glucosamine-Dy Complex

REN Xiang-qun ZHAI Yu-chun GE Xin QIN Yan

Received:2008-05-08 Revised:2008-07-22 Online:2008-10-20 Published:2008-10-20

摘要/Abstract

摘要： 用D-氨基葡萄糖盐酸盐与氯化镝反应，制备了氨基葡萄糖-镝配合物. 用元素分析、电导率、红外光谱、紫外光谱、X射线光电子能谱等分析测试手段对配合物进行了表征. 以EDTANa2×Fe(II)-H2O2体系产生羟自由基(×OH)研究氨基葡萄糖与氨基葡萄糖-镝配合物对羟自由基的清除作用. 结果表明，氨基葡萄糖与Dy3+形成了配合物，其中氨基葡萄糖氨基上的N和仲羟基的O及Cl-参与了配位. 该配合物对×OH均具有明显的清除作用，在浓度为2.5 mg/mL时对×OH的清除率达到85%，D-氨基葡萄糖对×OH的清除率达到77%. 各样品对×OH自由基的清除能力均随着质量浓度的增加而上升.

关键词: 氨基葡萄糖, Dy3+离子, 氨基葡萄糖-镝配合物, 合成, 羟自由基

Abstract: The coordination compound of glucosamine-Dy was synthesized from D-glucosamine hydrochloride with Dy3+ ion, and characterized by elemental analysis, molar conductivity, IR, UV-Vis and XPS, respectively. The scavenging effects of D-glucosamine and glucosamine-Dy complex on hydroxyl free radical produced by EDTANa2×Fe(II)-H2O2 system were studied. The results showed that Dy3+ ions were coordinated with amino groups, secondary hydroxyl groups and Cl-. D-glucosamine and glucosamine-Dy complex had significant scavenging effects on hydroxyl free radical. The glucosamine-Dy complex displayed higher scavenging effects on the hydroxyl free radical compared with glucosamine when mass concentration of the sample was 2.5 mg/mL, the removal rate of glucosamine-Dy complex on hydroxyl free radical reached 85%, and that of D-glucosamine was 77%. The removal rates of D-glucosamine and glucosamine-Dy complex on hydroxyl free radical increased with their mass concentrations.

Key words: glucosamine, Dy3+ ion, glucosamine-Dy complex, synthesis, hydroxyl free radical

中图分类号:

任群翔翟玉春葛欣秦岩 . 氨基葡萄糖-镝配合物的合成和抗羟自由基活性[J]. , 2008, 8(5): 967-971.

REN Xiang-qun ZHAI Yu-chun GE Xin QIN Yan. Synthesis and Anti-hydroxyl Free Radical Activity of Glucosamine-Dy Complex[J]. , 2008, 8(5): 967-971.

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