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›› 2014, Vol. 14 ›› Issue (6): 1000-1004.

• 生化工程专栏 • 上一篇    下一篇

PEG@Gd2O3:Tb复合中空纳米粒子的合成及其药物缓释性能

黄长水 酒红芳 贾万宝 常建霞 焦红倩   

  1. 中北大学理学院 中北大学理学院 中北大学理学院 中北大学理学院 中北大学理学院
  • 收稿日期:2014-10-13 修回日期:2014-11-04 出版日期:2014-12-20 发布日期:2014-12-20
  • 通讯作者: 酒红芳

Synthesis and Drug Release Performance of Hollow PEG@Gd2O3:Tb Hybrid Nanoparticles

HUANG Chang-shui JIU Hong-fang JIA Wan-bao CHANG Jian-xia JIAO Hong-qian   

  1. College of science,North university of China College of science,North university of China College of science,North university of China College of science,North university of China College of science,North university of China
  • Received:2014-10-13 Revised:2014-11-04 Online:2014-12-20 Published:2014-12-20
  • Contact: JIU Hong-fang

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被引次数

2

摘要： 以稀土硝酸盐-乙二醇-硝酸混合溶液为前驱体，通过一步水热法合成无机/有机复合中空纳米粒子PEG@Gd2O3:Tb，对样品进行了表征，研究了其药物缓释性能. 结果表明，所得纳米粒子具有无机/有机复合中空结构，直径约200 nm，球壁厚度约20 nm，经800℃高温处理后为立方相的Gd2O3. 载药后的杂化中空纳米粒子比纯Gd2O3的释药速率更低，药物持续释放时间可达24 h，载药量为261.5 mg/g. 复合中空纳米粒子综合了无机纳米粒子的刚性和有机物质的韧性及生物相容性，拓展了空心球的潜在应用价值，在载药方面具有应用潜力.

关键词: 水热法, 无机/有机复合中空结构, 纳米粒子, 生物相容性, 药物缓释

Abstract: PEG@Gd2O3:Tb3+ hybrid hollow nanoparticles were synthesized by one-step hydrothermal method, and characterized. The results show that the diameter of hybrid hollow nanoparticles is 200 nm, and the wall thickness 100 nm. They can be regulated by suitable modification. Compared with the calcined hollow Gd2O3:Tb3+, the hybrid hollow nanoparticles exhibit lower release rate due to PEG. The system shows a slow release and complete release after 24 h, the loading amount of doxorubincin in PEG@Gd2O3:Tb3+ hollow spheres is 261.5 mg/g. They may find potential applications in the fields such as drug delivery and biological labeling because of their excellent biocompatibility and luminescence properties.

Key words: hydrothermal method, inorganic/organic hybrid hollow structure, nanoparticle, biocompatibility, drug delivery

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