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›› 2006, Vol. 6 ›› Issue (2): 289-295.

• 材料工程专栏 • 上一篇    下一篇

Preparation and Characterization of Copolymer Micelles Formed by Poly(ethylene glycol)-Polylactide Block Copolymers as Novel Drug Carriers

姜维,王运东,甘泉,张建铮,赵秀文,费维扬,贝建中,王身国   

  1. 清华大学化工系
  • 出版日期:2006-04-20 发布日期:2006-04-20

Preparation and Characterization of Copolymer Micelles Formed by Poly(ethylene glycol)-Polylactide Block Copolymers as Novel Drug Carriers

JIANG Wei,WANG Yun-dong,GAN Quan,ZHANG Jian-zheng,ZHAO Xiu-wen,FEI Wei-yang,BEI Jian-zhong,WANG Shen-guo   

  1. Department of Chemical Engineering, Tsinghua University
  • Online:2006-04-20 Published:2006-04-20

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摘要： Diblock copolymer poly(ethylene glycol) methyl ether-polylactide (MePEG-PLA) micelles were prepared by dialysis against water. Indomethacin (IMC) as a model drug was entrapped into the micelles by dialysis method. The critical micelle concentration (CMC) of the prepared micelles in distilled water investigated by fluorescence spectroscopy was 0.0051 mg/mL which is lower than that of common low molecular weight surfactants. The diameters of MePEG-PLA micelles and IMC loaded MePEG-PLA micelles in number-averaged scale measured by dynamic light scattering were 52.4 and 53.7 nm respectively. Transmission electron microscope and scanning electron microscope observation showed that the appearance of MePEG-PLA micelles was in a spherical shape. The content of IMC incorporated in the core portion of the micelles was 18 wt.%. The effects of the synthesis method of the copolymer on the polydispersity of the micelles and the yield of the micelles formation were discussed.

关键词: poly(ethylene glycol), polylactide, block copolymer, polymer micelle, drug carrier

Abstract: Diblock copolymer poly(ethylene glycol) methyl ether-polylactide (MePEG-PLA) micelles were prepared by dialysis against water. Indomethacin (IMC) as a model drug was entrapped into the micelles by dialysis method. The critical micelle concentration (CMC) of the prepared micelles in distilled water investigated by fluorescence spectroscopy was 0.0051 mg/mL which is lower than that of common low molecular weight surfactants. The diameters of MePEG-PLA micelles and IMC loaded MePEG-PLA micelles in number-averaged scale measured by dynamic light scattering were 52.4 and 53.7 nm respectively. Transmission electron microscope and scanning electron microscope observation showed that the appearance of MePEG-PLA micelles was in a spherical shape. The content of IMC incorporated in the core portion of the micelles was 18 wt.%. The effects of the synthesis method of the copolymer on the polydispersity of the micelles and the yield of the micelles formation were discussed.

Key words: poly(ethylene glycol), polylactide, block copolymer, polymer micelle, drug carrier