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›› 2008, Vol. 8 ›› Issue (4): 774-778.

• 生化工程专栏 • 上一篇    下一篇

超声强化溴化1-乙基-3-甲基咪唑从黄花蒿中提取青蒿素

夏禹杰 曾建立 赵兵   

  1. 中国科学院过程工程研究所生化工程国家重点实验室 中国科学院过程工程研究所生化工程国家重点实验室 中国科学院过程工程研究所
  • 收稿日期:2008-04-01 修回日期:2008-05-22 出版日期:2008-08-20 发布日期:2008-08-20
  • 通讯作者: 赵兵

Extraction of Artemisinin from Artemisia annual L. with 1-Ethyl-3-methylimidazolium Bromide Enhanced by Ultrasonic Wave

XIA Yu-jie ZENG Jian-li ZHAO Bing   

  1. National Key Lab BiochemEng, Institute of Process Engineering, Chinese Academy of Sciences State Key Laboratory of Biochemical Engineering, Institute of Process Engineering ,Chinese Academy of Sciences Inst. Process Eng., Chinese Academy of Sciences
  • Received:2008-04-01 Revised:2008-05-22 Online:2008-08-20 Published:2008-08-20
  • Contact: ZHAO Bing

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被引次数

18

摘要： 利用超声强化[emim]Br(溴化1-乙基-3-甲基咪唑)-水体系从黄花蒿粉末中提取青蒿素. 正交实验和单因素实验结果表明，影响黄花蒿中青蒿素提取因素的显著性次序为液固比>提取时间>提取温度>超声波功率>占空比. 综合考虑单因素实验结果及成本，得出优化工艺条件为黄花蒿原料粒度0.38 mm，液固比50 mL/g，提取时间30 min，提取温度20℃，超声波功率600 W，占空比1.6 s/0.4 s. 在上述条件下青蒿素提取量为4.37 mg/g，提取率为97%.

关键词: 青蒿素, 黄花蒿, 溴化1-乙基-3-甲基咪唑, 超声强化提取

Abstract: Extraction of artemisinin from Artemisia annual L. using ionic liquid [emim]Br (1-ethyl-3-methylimidazolium bromide)- water system enhanced by ultrasonic wave was investigated. Through orthogonal and single factor experiments, the results showed that the sequence of notability of artemisinin extraction factors was: liquid-to-solid ratio > extraction time > extraction temperature > ultrasonic wave power > duty ratio. Comprehensively considering single factor experiments and production cost, the optimum extraction conditions were obtained as Artemisia annual L. granularity at 0.38 mm, liquid-to-solid ratio 50 mL/g, extraction time 30 min, extraction temperature 20℃, ultrasonic wave power 600 W and duty ratio 1.6 s/0.4 s. Under the above conditions, the extraction amount of artemisinin was 4.37 mg/g and the extraction rate 97%.

Key words: artemisinin, Artemisia annual L., 1-ethyl-3-methylimidazolium bromide, ultrasonic wave enhanced extraction

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