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›› 2010, Vol. 10 ›› Issue (2): 332-338.

• 生化工程专栏 • 上一篇    下一篇

Storage Stability of Alpha-Lipoic Acid-loaded Lipid Nanoparticles

唐金国 夏强 刘光煜   

  1. 东南大学生物电子学国家重点实验室 东南大学分子与生物电子学教育部重点实验室纳米科学与技术研究中心 东南大学分子与生物电子学教育部重点实验室纳米科学与技术研究中心
  • 收稿日期:2009-11-20 修回日期:2010-01-18 出版日期:2010-04-20 发布日期:2010-04-20
  • 通讯作者: 夏强

Storage Stability of Alpha-Lipoic Acid-loaded Lipid Nanoparticles

TANG Jin-guo, XIA Qiang LIU Guang-yu   

  1. State Key laboratory of Bioelectronics, Southeast University Key Lab. Mol. Biomol. Electr., Ministry of Education, Res. Cent. Nano-scale Sci. & Technol., Southeast Univ. Key Lab. Mol. Biomol. Electr., Ministry of Education, Res. Cent. Nano-scale Sci. & Technol., Southeast Univ.
  • Received:2009-11-20 Revised:2010-01-18 Online:2010-04-20 Published:2010-04-20
  • Contact: XIA Qiang

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摘要： Alpha-lipoic acid-loaded lipid nanoparticles (ALA-LNs) were prepared by high pressure homogenization method. The influences of storage conditions such as time and temperature on the physical and chemical storage stability of ALA-LNs were studied in details. The stability was evaluated by particle size and polydispersity index, morphology of ALA-LNs, and capacity of ALA loading. The dilution and pH stability of ALA-LNs suspensions were also studied. After three months storage, the mean size of ALA-LNs at 4 and 40℃ was increased by 2.68% and 3.62% compared with the original size, respectively. ALA-LNs stored at 40℃ had ellipsoid shape and the mean size was about 152 nm (SD=23.6). The loading capacity of ALA at 40℃ was much higher than those stored at other two temperatures. The good dilution and pH stability were also demonstrated. The sample had good fluidity even at 4℃.

关键词: alpha-lipoic acid, lipid nanoparticles, storage stability, particle size, particle morphology

Abstract: Alpha-lipoic acid-loaded lipid nanoparticles (ALA-LNs) were prepared by high pressure homogenization method. The influences of storage conditions such as time and temperature on the physical and chemical storage stability of ALA-LNs were studied in details. The stability was evaluated by particle size and polydispersity index, morphology of ALA-LNs, and capacity of ALA loading. The dilution and pH stability of ALA-LNs suspensions were also studied. After three months storage, the mean size of ALA-LNs at 4 and 40℃ was increased by 2.68% and 3.62% compared with the original size, respectively. ALA-LNs stored at 40℃ had ellipsoid shape and the mean size was about 152 nm (SD=23.6). The loading capacity of ALA at 40℃ was much higher than those stored at other two temperatures. The good dilution and pH stability were also demonstrated. The sample had good fluidity even at 4℃.

Key words: alpha-lipoic acid, lipid nanoparticles, storage stability, particle size, particle morphology

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