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›› 2006, Vol. 6 ›› Issue (3): 380-383.

• 反应与分离 • 上一篇    下一篇

解吸-内部沸腾两步法提取黄连小檗碱的工艺及机理

韦藤幼,赵钟兴,童张法   

  1. 广西大学化学化工学院
  • 出版日期:2006-06-20 发布日期:2006-06-20

Technology and Mechanism for Extracting Berberine from Rhizoma coptidis by Two Steps of Releasing and Inner Ebullitio

WEI Teng-you,ZHAO Zhong-xing,TONG Zhang-fa   

  1. School of Chemistry and Chemical Engineering,Guangxi University,Nanning
  • Online:2006-06-20 Published:2006-06-20

摘要: 采用解吸-内部沸腾两步法强化植物有效成分提取,首先用少量低沸点解吸剂饱和植物组织,以使组织内部的有效成分充分解吸,然后快速加入温度高于解吸剂沸点的溶剂,使植物组织内部的解吸剂迅速被加热至沸腾,强化传质过程. 对黄连中的小檗碱提取实验结果表明,两步法提取2次只需6 min,提取浸膏中小檗碱含量达到53.3%,颗粒度在160~400 mm范围内对提取效果基本没有影响. 热水温度影响实验发现,当内部沸腾发生时提取速度发生突变. 两步法提取黄连不但比传统法优势明显,而且容易实现,应用前景良好.

关键词: 两步法, 提取, 黄连, 机理, 小檗碱

Abstract: A two-step method of releasing and inner ebullition was used to intensify the process of extracting berberine in the plant of Rhizoma coptidis. In this method, a little lower boiling point release-solvent was first used to saturate the plant so that the activated component inside the plant could be released adequately, and then the solvent in which temperature was higher than the lower boiling point was added rapidly, as a result, the release-solvent inside the plant was heated to boiling and the mass transfer was intensified. The experimental results of extracting berberine from Rhizoma coptidis showed that the two steps of extraction only needed 6 min, the concentration of berberine in the extract was 53.5% and the granule sizes between 160 and 400 mm did not take effect on the extraction. Compared with the traditional extraction methods, the two-step extraction of Rhizoma coptidis is not only more advantageous, but also more easily performed. It is expected to have a promising future in application.

Key words: two-step, extraction, Rhizoma coptidis, mechanis, berberine