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›› 2007, Vol. 7 ›› Issue (6): 1249-1253.

• 材料工程专栏 • 上一篇    下一篇

多形貌萘普生药物晶体生长的可视化研究

金康康,程靖,文利雄,陈建峰   

  1. 北京化工大学教育部超重力工程研究中心
  • 出版日期:2007-12-20 发布日期:2007-12-20

Visual Study on the Formation of Naproxen Particles with Different Morphologies

JIN Kang-kang,CHENG Jing,WEN Li-xiong,CHEN Jian-feng   

  1. Research Center of the Ministry of Education for High Gravity Engineering and Technology, Beijing University of Chemical Technology
  • Online:2007-12-20 Published:2007-12-20

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摘要： 采用毛细显微摄像技术对反应结晶法制备多形貌萘普生药物的晶体生长进行了直观、实时的观察和研究. 实验考察了表面活性剂种类和浓度、药物浓度及反应温度对生成的萘普生结晶颗粒形貌和尺寸的影响，并对颗粒的生长机理进行了讨论. 结果表明，在表面活性剂Tween-80, PVP, Karomic-90或CMC的作用下，可分别得到针状、球状、蝴蝶状及棒状萘普生晶体，药物浓度、表面活性剂浓度及反应温度对萘普生晶体的尺寸均有显著的影响.

关键词: 萘普生, 表面活性剂, 晶体生长, 可视化

Abstract: A new technology was proposed to visually study the crystallization morphologies of naproxen particles synthesized by reaction-precipitation. The effects of surfactant type and concentration, naproxen concentration and reacting temperature on the morphology and size of the synthesized naproxen particles were investigated, and the growth mechanism of particles was discussed briefly. It was found that needle-like, spherical, butterfly-like and rod-like crystals of naproxen particles could be obtained respectively in the presence of Tween-80, PVP, Karomic-90 or CMC. Naproxen concentration, surfactant concentration and reacting temperature could also influence the particle size significantly.

Key words: naproxen, surfactant, crystallization, visualization