Preparation of Triptorelin Acetate-loaded PLGA Microspheres by Premix Membrane Emulsification
WANG Ning WANG Yu-xia QIN Pei-yong WEI Yi MA Guang-hui
College of Life Science and Technology, Beijing University of Chemical Technology State Key Lab of Biochemical Engineering, Institute of Process Engineering, CAS College of Life Science, Beijing University of Chemical Technology State Key Lab of Biochemical Engineering, Institute of Process Engineering, CAS State Key Lab. Biochem. Eng., Inst. Process Eng., Chinese Academy of Sciences
Abstract： Triptorelin acetate loaded biodegradable poly(lactic-co-glycolic acid) (PLGA) uniform-sized microspheres were prepared by a method combining premix membrane emulsification and solvent evaporation with high concentration (160 g/L) gelatin as water phase and methylene chloride containing high concentration (500 g/L) PLGA as oil phase. It was possible for the drug completely entrapped by the PLGA microcapsules. The mean diameter of PLGA microspheres was about 30 mm, the encapsulation efficiency of triptorelin acetate 80.12%, and Span (coefficient of size distribution) value less than 0.8. Subsequently, the cumulative release rate of PLGA microspheres loading triptorelin in vitro for 36 d was 72.60%. Furthermore, the release profile of the drug in vitro was well for controlled release.
王宁 王玉霞 秦培勇 韦祎 马光辉. 快速膜乳化法制备载醋酸曲普瑞林PLGA微球[J]. , 2013, 13(5): 862-869.
WANG Ning WANG Yu-xia QIN Pei-yong WEI Yi MA Guang-hui. Preparation of Triptorelin Acetate-loaded PLGA Microspheres by Premix Membrane Emulsification. , 2013, 13(5): 862-869.
2013, Vol. 13 
