欢迎访问过程工程学报, 今天是

›› 2005, Vol. 5 ›› Issue (1): 44-48.

• 过程与工艺 • 上一篇    下一篇

Friedel-Crafts反应制备乙酰化聚苯乙烯型载体

卞国建,魏荣卿,刘晓宁,王强,欧阳平凯   

  1. 南京工业大学制药与生命科学学院
  • 出版日期:2005-01-20 发布日期:2005-01-20

Preparation of Acetylized Polystyrene Carrier by Friedel Crafts Acetylation Reaction

BIAN Guo-jian,WEI Rong-qing,LIU Xiao-ning,WANG Ning,OUYANG Ping-kai   

  1. College of Life Science and Pharmaceutical Engineering, Nanjing University of Technology
  • Online:2005-01-20 Published:2005-01-20

摘要: 通过Friedel Crafts酰基化反应制备了功能化乙酰基聚苯乙烯(PS)载体. 该载体经Mannich反应胺化后可替代氯甲基树脂制备的胺基树脂用作酶的固定化载体及制备离子交换树脂. 此法避免了氯甲基树脂生产中使用氯甲醚等致癌物质及多取代、二次交联等副反应的问题. 考察了反应时间、催化剂和酰基化试剂用量、溶剂体系及溶剂用量等对PS乙酰化反应的影响,优化了反应条件,制得乙酰基PS最大担载量可达5.9 mmol/g,并在此范围内可定量获得预期担载量的乙酰基PS载体.

关键词: Friedel-Crafts, 酰基化反应, 功能化, 乙酰基聚苯乙烯, 乙酰基的定量担载

Abstract: The functional acetylized polystyrene particles were prepared by Friedel Crafts acetylation on polystyrene (PS). The obtained particles may be used as the solid support in flexible immobilization of enzyme, and ion exchange and adsorption. The reported method avoided the toxic problem caused by classic chloromethylation process and eliminated side reactions such as multi-substitution and secondary cross link. In this work, the effects of catalyst, acylating reagent, time and solvent were studied to achieve optimum results. By controlling the amount of materials (catalyst, acylating reagent), the quantitative loading of acetylized resin could be attained. The maximum loading of the acetyl polystyrene could be to 5.9 mmol/g.

Key words: Friedel-Crafts, acetylation, functional, acetylized polystyrene, quantitative loading