Abstract：The heterogenous Friedel-Crafts acylation of anisole with acetic anhydride using Hb zeolite as catalyst was carried out without any solvent. p-Methoxy acetophenone selectively and rapidly formed on the fresh zeolite catalyst. The effects of molar ratio of reactants, dosage of catalyst and reaction temperature on the yield of products were investigated. Under the feasible reaction conditions of anisole (AN) of 0.1 mol, anisole/acetic anhydride (AN/AA) molar ratio of 1:1.5, catalyst dosage of 1.0 g, reaction temperature of 95℃ and reaction time of 4 h, the highest yield of p-methoxy acetophenone was achieved up to 73.25%. The reaction kinetics was studied by Langmuir-Hinshelwood model. The adsorption equilibrium constants (AEC) for reactants and products as well as the rate constants for the acylation reaction were obtained respectively based on hypotheses of quasi-initial and quasi-stationary states. The result showed that the competitive adsorption effects of reactants and products resulted from differences in their adsorption equilibrium constants. The estimated values of AEC indicated that the acylation product p-methoxyacetophenone was adsorbed strongly more than the reactants. The AEC values of p-methoxyacetophenone decreased with the increase in reaction temperature.
陈平 翟玉春. Hb沸石催化合成对甲氧基苯乙酮及其反应物与产物的竞争吸附[J]. , 2010, 10(1): 70-74.
CHEN Ping ZHAI Yu-chun. Synthesis of p-Methoxyacetophenone Catalysed with Hb Zeolite and Competitive Adsorption of the Reactants and Products. , 2010, 10(1): 70-74.