欢迎访问过程工程学报, 今天是

›› 2004, Vol. 4 ›› Issue (6): 513-518.

• 过程与工艺 • 上一篇    下一篇

以三聚氰胺甲醛微球为模板的空腔胶囊的制备与应用

刘亚军,朱以华,张素秋,杨晓玲   

  1. 华东理工大学超细材料制备与应用教育部重点实验室
  • 出版日期:2004-12-20 发布日期:2004-12-20

Production and Application of Hollow Capsules Templated on Melamine-formaldehyde Microspheres

LIU Ya-jun,ZHU Yi-hua,ZHANG Su-qiu,YANG Xiao-ling   

  1. Key Lab. Ultrafine Mat. Min. Edu., East China Univ. Sci. & Technol.
  • Online:2004-12-20 Published:2004-12-20

PDF

被引次数

27

摘要： 以低度交联的单分散三聚氰胺甲醛(MF)微球作为胶体模板，采用逐层静电自组装技术，交替组装正负聚电解质，得到具有核壳结构的复合微球，然后利用盐酸溶液分解掉模板MF，从而形成均匀的空腔胶囊；并以盐酸阿霉素为例，对空腔胶囊的载药量及缓释性进行了初步研究. 结果显示，胶囊载药量可达27.07 μg/mL，胶囊对药物具有显著的缓释作用，释放半衰期t1/2=17.5 h.

关键词: 逐层自组装, 核壳式微球, 空腔胶囊, 载药

Abstract: Uniform hollow capsules were produced by the layer-by-layer electrostatic self-assembly technique. The core-shell microspheres were prepared by alternately depositing negative and positive polyelectrolytes onto the weakly-crosslinked MF microspheres which were used as solid templates, then the templates were decomposed by 0.1 mol/L hydrochloric acid to get hollow capsules. The loaded drug amount and controlled release from the capsules were tested using Dexorubicin hydrochloride as the model medicine. The result shows that the loaded drug amount in the capsules is 27.07 μg/mg and capsules can slow down the release of Dexorubicin remarkably.

Key words: layer-by-layer self-assembly, core-shell microsphere, hollow capsule, drug load