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›› 2012, Vol. 12 ›› Issue (6): 1038-1042.

• 材料工程专栏 • 上一篇    下一篇

水溶性壳聚糖稀土配合物的合成、表征及其抑菌性研究

吴锦绣 李梅 柳召刚 胡艳宏 王觅堂   

  1. 内蒙古科技大学稀土学院 内蒙古科技大学材料与冶金学院 内蒙古科技大学材料与冶金学院 内蒙古科技大学材料与冶金学院 内蒙古科技大学材料与冶金学院
  • 收稿日期:2012-12-13 修回日期:1900-01-01 出版日期:2012-12-20 发布日期:2012-12-20
  • 通讯作者: 吴锦绣

Study on Synthesis, Characterization and Antibacterial Activity of Rare Earth Complexes with Water-soluble Chitosan

WU Jin-xiu LI Mei LIU Zhao-gang HU Yan-hong WANG Mi-tang   

  1. College of Rare earth, Inner Mongolia University of Science and Technology Inner Mongolia Science and Technology University Material institute Inner Mongolia Science and Technology University Material institute Inner Mongolia Science and Technology University Material institute Inner Mongolia Science and Technology University Material institute
  • Received:2012-12-13 Revised:1900-01-01 Online:2012-12-20 Published:2012-12-20
  • Contact: WU Jin-xiu

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摘要： 以水溶性壳聚糖(CS)与稀土离子La3+, Nd3+, Sm3+, Eu3+和Dy3+在常温和pH值为4~5的条件下制备了水溶性壳聚糖稀土配合物CS-La, CS-Nd, CS-Sm, CS-Eu和CS-Dy. 并运用FT-IR, UV和TG-DTA对其配合物进行表征，并研究了配体和配合物的热稳定性及配合物的抑菌活性. 结果表明，5种配合物均有选择性抑菌性能；其对大肠杆菌和金黄色葡萄球菌均有很好的抑菌作用；其对5种菌的最小抑菌浓度(MIC)为120~500 mg/mL，低于800 mg/mL，且抑菌效果明显优于单独的壳聚糖和稀土硝酸盐. CS-Sm对大肠杆菌的抑菌性最好，MIC为125 mg/mL；而CS-Nd和CS-Sm对金黄色葡萄球菌的抑菌性最强，MIC均为120 mg/mL.

关键词: 水溶性壳聚糖, 稀土, 合成, 表征, 抑菌性能

Abstract: Rare earth-chitosan complexes (CS-La, CS-Nd, CS-Sm, CS-Eu and CS-Dy) were prepared by natural water-soluble chitosan (CS) and rare earth ions (La3+, Nd3+, Sm3+, Eu3+ and Dy3+) in aqueous solution at pH value from 4 to 5 under room temperature, and characterized by FT-IR, UV and TG-DTA. The antibacterial activity of rare earth-chitosan complexes, water-soluble chitosan and rare earth nitrate were also examined. The result of antibacterial activity test showed that the five complexes all had selective antibacterial property, and good bacteriostatic effect to Escherichia coli and Staphylococcus aureus. The minimal inhibitory concentration (MIC) of the five bacteria (Escherichia coli, Staphylococcus aureus, Proteus species, Candida albicans, and Pseudomonas aeruginosa) ranged from 120 to 500 μg/mL, less than 800 μg/mL. The antibacterial activity of complexes was superior to that of water-soluble chitosan and rare earth nitrate. The antibacterial property of CS-Sm to Echerichia coli was the best, its MIC 125 μ g/mL. While, that of CS-Nd and CS-Sm to Staphylococcus aureus was the best, and both of the MIC were 120 μg/mL.

Key words: water-soluble chitosan, rare earth, synthesis, characterization, antibacterial property

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