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›› 2009, Vol. 9 ›› Issue (4): 776-780.

• 生化工程专栏 • 上一篇    下一篇

以碳酸钙微球为模板的生物相容微胶囊的制备

金谊 朱以华 刘望才 王家荣 房江华   

  1. 宁波工程学院化工学院，聚合工程与技术宁波市重点实验室 华东理工大学超细材料制备与应用教育部重点实验室 宁波工程学院化工学院，聚合工程与技术宁波市重点实验室 宁波工程学院化工学院，聚合工程与技术宁波市重点实验室 宁波工程学院化工学院，聚合工程与技术宁波市重点实验室
  • 收稿日期:2009-02-18 修回日期:2009-04-30 出版日期:2009-08-20 发布日期:2009-08-20
  • 通讯作者: 金谊

Preparation of Biocompatible Microcapsules Templated on Calcium Carbonate Microspheres

JIN Yi, ZHU Yi-hua, LIU Wang-cai, WANG Jia-rong, FANG Jiang-hua,   

  1. Key Laboratory for Polymerization Engineering and Technology of Ningbo, Institute of Chemistry and Engineering, Ningbo University of Technology Key Lab. Ultrafine Mat. Min. Edu., East China Univ. Sci. & Technol. Key Laboratory for Polymerization Engineering and Technology of Ningbo, Institute of Chemistry and Engineering, Ningbo University of Technology Key Laboratory for Polymerization Engineering and Technology of Ningbo, Institute of Chemistry and Engineering, Ningbo University of Technology Key Laboratory for Polymerization Engineering and Technology of Ningbo, Institute of Chemistry and Engineering, Ningbo University of Technology
  • Received:2009-02-18 Revised:2009-04-30 Online:2009-08-20 Published:2009-08-20
  • Contact: JIN Yi,

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摘要： 以CaCl2和Na2CO3为原料，通过结晶生长制备了掺杂聚苯乙烯磺酸钠(PSS，直径为4~5 mm)的CaCO3颗粒，探讨了PSS功能团与钙离子的摩尔比([PSS]/[Ca2+])对其形貌和晶型的影响，并以合成的CaCO3微球为模板，采用层层自组装技术将具有相反电荷的鱼精蛋白和硫酸葡聚糖交替组装到微球表面，除去模板后得到了具有生物相容性的空腔胶囊，并以绿原酸为缓释物对微胶囊的缓释性能进行了研究. 结果表明，微胶囊的包封率和载药量分别为83.55%和37.41 mg/mg，对绿原酸具有明显的缓释效果.

关键词: 碳酸钙, 微胶囊, 模板, 层层自组装

Abstract: Poly(sodium 4-styrenesulfonate) (PSS) was used to synthesize calcium carbonate (CaCO3) microspheres with different morphologies. The influences of different functional group unit molar ratios of [PSS]/[Ca2+] on the morphology and crystal phases of CaCO3 microspheres were studied by high scan electrode microscope and X-ray diffraction. These synthesized microspheres were used as the template of microcapsules. Protamine sulfate (PRM) and dextran (DXS) were self-assembled on the surface of obtained microshperes by layer-by-layer self-assembly technique. After the CaCO3 was dissolved, the microcapsules were obtained. The controlled release behavior of hollow capsules was examined in the sample of chlorogenic acid. The result shows that the encapsulated rate and loaded drug amount were 83.55% and 37.41 mg/mg, respectively. The (DXS/PRM)6 capsules demonstrated obvious controlled release effect.

Key words: CaCO3, microcapsules, template, layer-by-layer self-assembly

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