Preparation of Lactose Particles Using Side Spray Technology in a Fluidized Bed
ZONG Rui-xia JING Qiu-fang MA Xiao-si REN Fu-zheng
Shanghai Key Laboratory of New Drug Design, East China university of science and technology Shanghai Key Laboratory of New Drug Design, East China university of science and technology Shanghai Key Laboratory of New Drug Design, East China university of science and technology Shanghai Key Laboratory of New Drug Design, East China university of science and technology
Abstract：Preparation of lactose particles in a fluidized bed was investigated using side spray technology. The particle size distribution and flowability were selected to evaluate the granulation with hydroxypropyl methylcellulose K4M as binding agent. Over 85%(j) of the particles were in the range of 200~355 mm when optimum formulation and process parameters were chosen, including the concentration of binding agent 1.5%(w), its mass increment 2%, spray rate 14~18 g/min, and atomization pressure 1.5′105 Pa. The slope of repose of granules (<34o) and degree of compression (<10%) showed the good flowability of lactose particles. The particles had a spherical shape, when observed under an optical microscope. The preparation process was very stable and had a good repeatability.
2012, Vol. 12 
