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›› 2011, Vol. 11 ›› Issue (5): 846-850.

• 生化工程专栏 • 上一篇    下一篇

蓝藻为载体的阿维菌素抗紫外缓释剂的制备及其性能

侯宏伟 任天瑞 燕云峰 王全喜 徐文平   

  1. 上海师范大学生命与环境科学学院 上海师范大学 生命与环境科学学院 上海师范大学 生命与环境科学学院 上海师范大学生命与环境科学学院 华东理工大学药学院
  • 收稿日期:2011-03-28 修回日期:2011-07-28 出版日期:2011-10-20 发布日期:2011-10-20
  • 通讯作者: 任天瑞

Preparation of Anti-UV Controlled Release Formulation of Avermectin with Carrier of Blue Algae and Its Property

HOU Hong-wei REN Tian-rui YAN Yun-feng WANG Quan-xi XU Wen-ping   

  1. College of Life and Environment Science, Shanghai Normal University College of Life and Environment Sciences, Shanghai Normal University College of Life and Environment Sciences, Shanghai Normal University College of Life & Environment Sciences, Shanghai Normal University College of Pharmacy, East China University of Science and Technology
  • Received:2011-03-28 Revised:2011-07-28 Online:2011-10-20 Published:2011-10-20
  • Contact: REN Tian-rui

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被引次数

5

摘要： 以滇池蓝藻为载体，利用其抗紫外特性，用卡波姆树脂包裹蓝藻-阿维菌素(Avermectin, Av)粉，制成阿维菌素抗紫外缓释剂，利用FT-IR, SEM和HPLC等对蓝藻和缓释剂进行表征，研究其吸附与释放行为. 结果表明，Av在异丙醇中的饱和吸附量为160.81 mg/g，包裹10%卡波姆树脂的抗紫外缓释剂具有很好的缓释功能，在乙醇/水(4:1, j)中释放20 d，累计释放率为51.8%，释放机制是Fick扩散和骨架溶蚀的双重机制. 经4 h紫外光照射，含蓝藻的制剂中Av残留量为61%，不含蓝藻的制剂中Av残留量为39%.

关键词: 蓝藻, 阿维菌素, 抗紫外缓释剂

Abstract: A major objective of the present work is to develop anti-UV controlled release formulation of avermectin (Av), with utilizing the anti-UV characteristic of blue algae as carrier taken from Dianchi Lake. Av was adsorbed on blue algae powder and then coated with 10% carbomer resin. The blue algae powder and release formulation were characterized by FT-IR, SEM and HPLC. The results show that the adsorptive capacity of Av is 160.81 mg/g in isopropanol at 25℃. The formulation release rate is 51.8% for 20 d in ethanol/water (4:1, j) at 25℃. The controlled release mechanism belongs to Fickian diffusion and matrix erosion. The residual rates of Av with blue algae and alone are 61.0% and 39.0% respectively under UV irradiating. It is improved that blue algae has the function of resistance against UV.

Key words: blue algae, avermactin, anti-UV controlled release formulation

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