Preparation of Anti-UV Controlled Release Formulation of Avermectin with Carrier of Blue Algae and Its Property
HOU Hong-wei REN Tian-rui YAN Yun-feng WANG Quan-xi XU Wen-ping
College of Life and Environment Science, Shanghai Normal University College of Life and Environment Sciences, Shanghai Normal University College of Life and Environment Sciences, Shanghai Normal University College of Life & Environment Sciences, Shanghai Normal University College of Pharmacy, East China University of Science and Technology
Abstract：A major objective of the present work is to develop anti-UV controlled release formulation of avermectin (Av), with utilizing the anti-UV characteristic of blue algae as carrier taken from Dianchi Lake. Av was adsorbed on blue algae powder and then coated with 10% carbomer resin. The blue algae powder and release formulation were characterized by FT-IR, SEM and HPLC. The results show that the adsorptive capacity of Av is 160.81 mg/g in isopropanol at 25℃. The formulation release rate is 51.8% for 20 d in ethanol/water (4:1, j) at 25℃. The controlled release mechanism belongs to Fickian diffusion and matrix erosion. The residual rates of Av with blue algae and alone are 61.0% and 39.0% respectively under UV irradiating. It is improved that blue algae has the function of resistance against UV.
侯宏伟 任天瑞 燕云峰 王全喜 徐文平. 蓝藻为载体的阿维菌素抗紫外缓释剂的制备及其性能[J]. , 2011, 11(5): 846-850.
HOU Hong-wei REN Tian-rui YAN Yun-feng WANG Quan-xi XU Wen-ping. Preparation of Anti-UV Controlled Release Formulation of Avermectin with Carrier of Blue Algae and Its Property. , 2011, 11(5): 846-850.
2011, Vol. 11 
