Abstract: Extraction of artemisinin from Artemisia annual L. using ionic liquid [emim]Br (1-ethyl-3-methylimidazolium bromide)- water system enhanced by ultrasonic wave was investigated. Through orthogonal and single factor experiments, the results showed that the sequence of notability of artemisinin extraction factors was: liquid-to-solid ratio > extraction time > extraction temperature > ultrasonic wave power > duty ratio. Comprehensively considering single factor experiments and production cost, the optimum extraction conditions were obtained as Artemisia annual L. granularity at 0.38 mm, liquid-to-solid ratio 50 mL/g, extraction time 30 min, extraction temperature 20℃, ultrasonic wave power 600 W and duty ratio 1.6 s/0.4 s. Under the above conditions, the extraction amount of artemisinin was 4.37 mg/g and the extraction rate 97%.

Key words: artemisinin, Artemisia annual L., 1-ethyl-3-methylimidazolium bromide, ultrasonic wave enhanced extraction

摘要： 利用超声强化[emim]Br(溴化1-乙基-3-甲基咪唑)-水体系从黄花蒿粉末中提取青蒿素. 正交实验和单因素实验结果表明，影响黄花蒿中青蒿素提取因素的显著性次序为液固比>提取时间>提取温度>超声波功率>占空比. 综合考虑单因素实验结果及成本，得出优化工艺条件为黄花蒿原料粒度0.38 mm，液固比50 mL/g，提取时间30 min，提取温度20℃，超声波功率600 W，占空比1.6 s/0.4 s. 在上述条件下青蒿素提取量为4.37 mg/g，提取率为97%.

关键词: 青蒿素, 黄花蒿, 溴化1-乙基-3-甲基咪唑, 超声强化提取