井冈霉素载药二氧化硅空心微球的原位制备及缓释性能评价

›› 2008, Vol. 8 ›› Issue (3): 595-598.

井冈霉素载药二氧化硅空心微球的原位制备及缓释性能评价

梁旭东李雪光付瑶文利雄陈建峰

北京化工大学纳米材料重点实验室北京化工大学纳米材料重点实验室北京化工大学纳米材料重点实验室北京化工大学纳米材料先进制备技术与应用科学教育部重点实验室北京化工大学纳米材料先进制备技术与应用科学教育部重点实验室

收稿日期:2008-01-22 修回日期:2008-03-25 出版日期:2008-06-20 发布日期:2008-06-20
通讯作者: 文利雄

In situ Preparation and Drug Release Properties of Validamycin-loaded Silica Hollow Microcapsules

LIANG Xu-dong LI Xue-guang FU Yao WEN Li-xiong CHEN Jian-feng

Key Lab for Nanomaterials, Ministry of Education， Beijing University of Chemical Technology Key Lab for Nanomaterials, Ministry of Education， Beijing University of Chemical Technology Key Lab for Nanomaterials, Ministry of Education， Beijing University of Chemical Technology Key Lab for Nanomaterials, Ministry of Education, Beijing University of Chemical Technology Key Lab for Nanomaterials, Ministry of Education,Beijing University of Chemical Technology

Received:2008-01-22 Revised:2008-03-25 Online:2008-06-20 Published:2008-06-20
Contact: WEN Li-xiong

摘要/Abstract

摘要： 利用正硅酸乙酯在W/O乳液中的原位水解聚合，成功制备了包埋井冈霉素的二氧化硅载药空心微球. 对所得产品进行了SEM, XRD, FT-IR和粒径分布等分析，结果表明，载药空心微球粒径分布窄，范围在7.5~15 mm，球状形貌良好，具有空心结构，呈无定型态. 热重分析表明载药空心微球的药物负载量约为31.9%(w)，缓释溶出实验显示载药空心微球药物释放持续时间约240 min，最终释放量达总载药量的90%以上.

关键词: 空心微球, 原位制备, 井冈霉素, 缓释, 二氧化硅

Abstract: Validamycin-loaded silica hollow microspheres were prepared by in situ hydrolysis of tetraethyl orthosilicate (TEOS) in Water-Oil (W/O) emulsions. The microspheres were characterized by SEM, XRD, FT-IR and particle size distribution. The results indicated that the drug-loaded microspheres had an amorphous hollow spherical structure with the diameters of 7.5~15 mm. The amount of validamycin entrapped in the microspheres was about 31.9%(w). Sustained-releasing studies showed that the release time was about 240 min and more than 90% of the loaded drug in the microspheres was delivered, indicating good sustained release behavior of the drug-loaded microspheres.

Key words: hollow microcapsules, in situ preparation, validamycin, sustained release, silica

中图分类号:

TQ450.6

梁旭东李雪光付瑶文利雄陈建峰. 井冈霉素载药二氧化硅空心微球的原位制备及缓释性能评价[J]. , 2008, 8(3): 595-598.

LIANG Xu-dong LI Xue-guang FU Yao WEN Li-xiong CHEN Jian-feng. In situ Preparation and Drug Release Properties of Validamycin-loaded Silica Hollow Microcapsules[J]. , 2008, 8(3): 595-598.

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