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›› 2011, Vol. 11 ›› Issue (3): 475-480.

• 生化工程专栏 • 上一篇    下一篇

甲氨基阿维菌素苯甲酸盐微囊藻缓释剂的制备及性能

巫娅坤 任天瑞 燕云峰 吴青海 王全喜 徐文平   

  1. 上海师范大学 生命与环境科学学院 上海师范大学 生命与环境科学学院 上海师范大学 生命与环境科学学院 上海师范大学 生命与环境科学学院 上海师范大学生命与环境科学学院 华东理工大学药学院
  • 收稿日期:2011-01-07 修回日期:2011-04-25 出版日期:2011-06-20 发布日期:2011-06-20
  • 通讯作者: 任天瑞

Preparation and Controlled Release Properties of Emamectin Benzoate with Microcystis as Carrier

WU Ya-kun REN Tian-rui YAN Yun-feng WU Qing-hai WANG Quan-xi XU Wen-ping   

  1. College of Life and Environment Sciences, Shanghai Normal University College of Life and Environment Sciences, Shanghai Normal University College of Life and Environment Sciences, Shanghai Normal University College of Life and Environment Sciences, Shanghai Normal University College of Life & Environment Sciences, Shanghai Normal University College of Pharmacy, East China University of Science and Technology
  • Received:2011-01-07 Revised:2011-04-25 Online:2011-06-20 Published:2011-06-20
  • Contact: REN Tian-rui

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摘要： 以微囊藻为吸附载体、卡波树脂为包衣剂，研制了甲氨基阿维菌素苯甲酸盐农药缓释剂，对微囊藻组成及形貌进行了表征，研究了微囊藻对甲维盐的吸附动力学和制剂的释放动力学. 结果表明，微囊藻的平均粒径为3.5 mm，表面存在大量的微孔和功能性基团，说明其具有很好的吸附作用；30℃下在1:1(j)乙醇水溶液中微囊藻对甲维盐的最大吸附量为70.78 mg/g，平均每个微囊藻吸附1.1×109个甲维盐分子；在3:7(j)乙醇水溶液中不含成膜剂的甲维盐-微囊藻缓释颗粒在24和72 h时的累积释放率分别为52.9%和65.3%，说明微囊藻具有对甲维盐的缓释应用前景.

关键词: 微囊藻, 甲氨基阿维菌素苯甲酸盐, g-氨基丁酸受体, 缓释剂

Abstract: Emamectin benzoate (EB) delivery formulation was prepared using microcystis (MC) as carrier and carbopol resin as matrix. The chemical composition and morphology of MC were investigated. Furthermore, the kinetics of MC adsorption to EB and the formulation release were carried out. MC particles with an average size of 3.5 mm exist with many micropores and abundant functional groups on their surface which presented the considerable binding ability with the maximum sorption capacities of EB on MC 70.78 mg/g, and 1.1×109 EB molecules per capsule in ethanol/water (1:1, j) at 30℃. The cumulative release quantities of granules without coating film agent are 52.9% and 65.3% during 24 and 72 h respectively. These results suggest that MC may have potential for EB controlled release formulation.

Key words: microcystis, emamectin benzoate, g-aminobutyric acid receptor, controlled release formulation

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