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›› 2013, Vol. 13 ›› Issue (6): 1020-1024.

• 生化工程专栏 • 上一篇    下一篇

以b-环糊精、2-羟丙基-b-环糊精和4-乙烯吡啶为功能单体制备氟比洛芬分子印迹聚合物及其吸附特征

江子滔 王李平 范华均 陈智 高啸巍 司徒伟良 潘宇 巫坤宏   

  1. 广东药学院药科学院 广东药学院药科学院 广东药学院基础学院 广东药学院药科学院 广东药学院药科学院 广东药学院药科学院 广东药学院药科学院 广东药学院药科学院
  • 收稿日期:2013-08-28 修回日期:2013-09-18 出版日期:2013-12-20 发布日期:2013-12-20
  • 通讯作者: 范华均

Preparation of Molecularly Imprinted Polymers for Flurbiprofen with b-Cyclodextrin, 2-Hydroxypropyl-b-Cyclodextrin and 4-Vinyl Pyridine as Functional Monomers and Their Adsorption Property

JIANG Zi-tao WANG Li-ping FAN Hua-jun CHEN Zhi GAO Xiao-wei TITU Wei-liang PAN Yu WU Kun-hong   

  1. College of Pharmacy, Guangdong Pharmaceutical University College of Pharmacy, Guangdong Pharmaceutical University College of Pharmacy, Guangdong Pharmaceutical University College of Pharmacy, Guangdong Pharmaceutical University College of Pharmacy, Guangdong Pharmaceutical University College of Pharmacy, Guangdong Pharmaceutical University College of Pharmacy, Guangdong Pharmaceutical University College of Pharmacy, Guangdong Pharmaceutical University
  • Received:2013-08-28 Revised:2013-09-18 Online:2013-12-20 Published:2013-12-20
  • Contact: FAN Hua-jun

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摘要： 以b-环糊精(β-CD)、2-羟丙基-β-环糊精(HP-β-CD)和4-乙烯吡啶(4-VP)为功能单体，以氟比洛芬为模板分子，以环氧氯丙烷和乙二醇二甲基丙烯酸酯为交联剂，采用本体聚合法制备分子印迹聚合物(MIPs)，对氟比洛芬与功能单体的相互作用和MIPs的结构进行了表征，比较了3种MIPs对氟比洛芬的吸附性能. 结果表明，β-CD, HP-β-CD和4-VP与氟比洛芬之间以较强的相互作用形成复合物，通过交联、聚合形成聚合物，以HP-β-CD作功能单体所得聚合物印迹效果最佳，具有较强的特异性吸附能力，印迹因子和特异性吸附率分别为1.79和38.92%，分子印迹机制是β-CD的锥筒包结作用和羟丙基的亲和作用形成印迹空穴.

关键词: 氟比洛芬, 分子印迹聚合物, β-环糊精, 2-羟丙基-β-环糊精, 4-乙烯吡啶, 吸附

Abstract: Using b-cyclodextrin (β-CD), 2-hydroxypropyl-b-Cyclodextrin (HP-b-CD) and 4-vinyl pyridine (4-VP) as functional monomers, the molecular imprinted polymers (MIPs) for flurbiprofen were synthesized by bulk polymerization, and their prepolymerization was characterized. MIPs were scanned by FT-IR for their chemical structure, and tested by static absorption for their adsorption properties. The results showed that b-CD, HP-β-CD and 4-VP had a certain interaction with flurbiprofen, their adsorption rate to flurbiprofen was more than 86.80%, but the MIP formed by HP-β-CD as functional monomer indicated better adsorption specificity for flurbiprofen with the imprinted factor 1.79 and specific adsorption rate 38.92%. Its specificity depended on the inclusion of cones and the affinity of 2-hydroxypropyl groups on HP-β-CD molecules.

Key words: flurbiprofen, molecularly imprinted polymer, β-cyclodextrin, 2-hydroxypropyl-β-cyclodextrin, 4-vinyl pyridine, adsorption

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