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›› 2011, Vol. 11 ›› Issue (1): 174-180.

• 综述 • 上一篇    

脂肪酶动力学拆分薄荷醇的研究进展

念保义 黄志华 罗菊香 牛玉   

  1. 三明学院化学与生物工程系 三明学院化学与生物工程系 三明学院化学与生物工程系 三明学院化学与生物工程系
  • 收稿日期:2010-11-10 修回日期:2011-02-21 出版日期:2011-02-20 发布日期:2011-02-20
  • 通讯作者: 念保义

Recent Research Development in Resolution Kinetics of Racemic Menthol by Lipase

NIAN Bao-yi HUANG Zhi-hua LUO Ju-xiang NIU Yu   

  1. Department of Chemistry and Biology Engineering, Sanming College Department of Chemistry and Biology Engineering, Sanming College Department of Chemistry and Biology Engineering, Sanming College Department of Chemistry and Biology Engineering, Sanming College
  • Received:2010-11-10 Revised:2011-02-21 Online:2011-02-20 Published:2011-02-20
  • Contact: NIAN Bao-yi

摘要: 从脂肪酶拆分薄荷醇的转酯化、水解反应的工艺和影响因素等方面,分析了脂肪酶动力学拆分过程的转酯化和水解反应的催化路径与特点,指出了脂肪酶拆分薄荷醇的最佳路径和工艺选择. 综述了近10年来脂肪酶拆分制备工业重要的手性香料l-薄荷醇的研究进展,特别综述了具有工业化前景的脂肪酶催化拆分和单元操作工艺的研究进展. 同时展望了未来脂肪酶拆分薄荷醇的研究方向.

关键词: l-薄荷醇, 脂肪酶拆分, 转酯化反应, 水解反应, 拆分工艺

Abstract: A condensed review of the potential offered by lipase for resolution of racemic menthols for the past 10 years is presented. Especially, recent applications of the lipase catalytic approach and industrialization of unit operation to the preparation of the most important flavor, l-menthol, are comprehensively covered by analyzing their processes of transesterification, hydrolysis reaction and influential factors. The potential industrial processes based on lipase-catalytic methods are discussed in the terms of their advantages over classical ones. The optimal pathway of resolution is achieved by analyzing resolving routes of menthol and alternative of acyl agent for transesterification of menthol. And a vista of the future investigations is opened up for new realms from macro-kinetics of menthol resolution for the industrial processes.

Key words: l-menthol, lipase resolution, esterification reaction, hydrolysis reaction, resolution process

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