沈阳农业大学 中国科学院过程工程研究所生化工程国家重点实验室 中国科学院过程工程研究所生化工程国家重点实验室 Shenyang Agriculture University 中国科学院过程工程研究所生化工程国家重点实验室
Preparation of mPEG-PLGA Porous Microspheres and Their Adsorption to Salcatonin
ZHANG Hui-xia WANG Yu-xia WEI Yi RUAN Yan-ye MA Guang-hui
Shenyang Agriculture University State Key Lab of Biochemical Engineering, Institute of Process Engineering, CAS State Key Lab of Biochemical Engineering, Institute of Process Engineering, CAS 沈阳农业大学 State Key Lab. Biochem. Eng., Inst. Process Eng., Chinese Academy of Sciences
Abstract：Relatively uniform size porous methoxy poly(ethylene glycol-L-lactic-co-glycolic acid) (mPEG-PLGA) microspheres were successfully prepared by premix membrane emulsification with solvent evaporate method. The effects of salcatonin concentration, salt concentration, pH value, adsorption temperature and time, and properties of microspheres on the adsorption capacity of salcatonin were investigated. The results showed that the adsorption capacity of porous microspheres reached 48.9 mg/g under the conditions of 1.0 mg/mL salcatonin concentration, pH value 7.4 of phosphate buffer, 0.2 mol/L NaCl concentration, 14℃ adsorption temperature and 8 h adsorption time. In addition, the adsorption capacity increased with the increase of specific surface area.
张慧霞 王玉霞 韦祎 阮燕晔 马光辉. mPEG-PLGA多孔微球的制备及其对降钙素的吸附行为[J]. , 2013, 13(5): 870-876.
ZHANG Hui-xia WANG Yu-xia WEI Yi RUAN Yan-ye MA Guang-hui. Preparation of mPEG-PLGA Porous Microspheres and Their Adsorption to Salcatonin. , 2013, 13(5): 870-876.
2013, Vol. 13 
