超临界CO2快速膨胀制备鱼腥草挥发油脂质体

›› 2009, Vol. 9 ›› Issue (2): 350-354.

超临界CO2快速膨胀制备鱼腥草挥发油脂质体

文震李琼李琼郑宗坤游新奎蒲一涛

深圳大学化学化工学院华南理工大学化工与能源学院华南理工大学化工与能源学院华南理工大学化工与能源学院华南理工大学化工与能源学院

收稿日期:2008-10-22 修回日期:2009-01-12 出版日期:2009-04-20 发布日期:2009-04-20
通讯作者: 文震

Preparation of Liposome of Volatile Oil from Houttuynia cordata Thunb. by Rapid Expansion of Supercritical Carbon Dioxide

WEN Zhen LIU Bo LI Qiong ZHENG Zong-kun YOU Xin-kui PU Yi-tao

College of chemistry and chemical engineering , Shenzhen University College of Chemical Engineering and Energy, South China University of Technology College of Chemical Engineering and Energy, South China University of Technology College of Chemical Engineering and Energy, South China University of Technology College of Chemical Engineering and Energy, South China University of Technology

Received:2008-10-22 Revised:2009-01-12 Online:2009-04-20 Published:2009-04-20
Contact: WEN Zhen

摘要/Abstract

摘要： 采用改进的超临界CO2快速膨胀方法制备了鱼腥草挥发油脂质体，并对其进行了表征. 考察了压力、温度、共溶剂乙醇用量等因素对脂质体制备的影响，在压力30 MPa、温度338 K及乙醇用量15%条件下，脂质体包封率为83.2%，载药量为5.2%，平均粒径为332.5 nm. 脂质体包封率、溶出度、稳定性等理化性质均符合中国药典的规定，载药量满足注射剂给药量的要求.

关键词: 脂质体, 超临界, 鱼腥草, 挥发油

Abstract: The liposome of volatile oil from Houttuynia cordata Thunb. was prepared by modified rapid expansion of supercritical solutions (RESS), and physicochemical properties of liposome were characterized. The effects of pressure, temperature of supercritical CO2 and cosolvent (CH3CH2OH) amount on the liposome formation process were examined. Entrapment rate, drug loading, and average size of liposome were obtained as 83.2%, 5.2% and 332.5 nm respectively under the conditions of 30 MPa, 338 K and CH3CH2OH 15%. The results showed that the physicochemical properties including entrapment rate, dissolution rate and stability conformed to the standards of Chinese pharmacopoeia, and drug loading met the needs of injection dosage.

Key words: liposome, supercritical, Houttuynia cordata Thunb., volatile oil

中图分类号:

TS201.2

文震李琼李琼郑宗坤游新奎蒲一涛. 超临界CO2快速膨胀制备鱼腥草挥发油脂质体[J]. , 2009, 9(2): 350-354.

WEN Zhen LIU Bo LI Qiong ZHENG Zong-kun YOU Xin-kui PU Yi-tao. Preparation of Liposome of Volatile Oil from Houttuynia cordata Thunb. by Rapid Expansion of Supercritical Carbon Dioxide[J]. , 2009, 9(2): 350-354.

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