Preparation of Microspheres of Paclitaxel-loaded PLA, PLGA and PELA by Premix Membrane Emulsification
ZENG Ye-jing, WANG Lian-yan, MA Guang-hui MA Guang-hui,
State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences . State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences State Key Lab. Biochem. Eng., Inst. Process Eng., Chinese Academy of Sciences School of Chemical Engineering, Beijing University of Chemical Technology
Abstract：Poly(lactic acid) (PLA) microspheres were prepared by premix membrane emulsification and compared with the results by homogenization and ultrasonification. The mean diameters of PLA microspheres prepared by homogenization and ultrasonification were 1.022 and 0.987 mm, and the corresponding polydispersities 0.133, 0.145, respectively, while the mean diameter of PLA microspheres by premix membrane emulsification was 0.906 mm and the polydispersity 0.005. Furthermore, the microspheres of paclitaxel (PTX) loaded PLA, PLGA [poly(lactic-co-glycolic acid)], PELA [poly(ethylene glycol-co-lactide acid)] with uniform size were prepared by premix membrane emulsification, and their encapsulation efficiency and cumulative release profiles in vitro were studied. The mean diameters of PTX-loaded PLA, PLGA and PELA microspheres were 0.906, 0.987 and 1.015 mm with the same polydispersity of 0.005. The corresponding drug loading efficiencies and encapsulation efficiencies were 3.89%, 4.93%, 3.18% and 63.2%, 71.6%, 51.3%, respectively. The cumulative release rates of PLA, PLGA, and PELA microspheres in vitro for 60 d were 83.87%, 50.25% and 41.27%.
曾烨婧 王连艳 马光辉 马润宇. 快速膜乳化法制备载紫杉醇聚乳酸类微球[J]. , 2010, 10(3): 568-575.
ZENG Ye-jing; WANG Lian-yan; MA Guang-hui MA Guang-hui;. Preparation of Microspheres of Paclitaxel-loaded PLA, PLGA and PELA by Premix Membrane Emulsification. , 2010, 10(3): 568-575.
2010, Vol. 10 
