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过程工程学报 ›› 2015, Vol. 15 ›› Issue (5): 847-853.DOI: 10.12034/j.issn.1009-606X.215263

• 生化工程专栏 • 上一篇    下一篇

快速膜乳化法制备尺寸均一的载硫酸亚铁明胶微球

张博 王瑛 王启宝 杨婷媛 张贵峰 王连艳   

  1. 中国矿业大学化学与环境工程学院 中国矿业大学化学与环境工程学院 中国矿业大学(北京)化学与环境工程学院 中国科学院过程工程研究所生化工程国家重点实验室 中国科学院过程工程研究所生化工程国家重点实验室 中国科学院过程工程研究所生化工程国家重点实验室
  • 收稿日期:2015-07-07 修回日期:2015-08-07 出版日期:2015-10-20 发布日期:2015-10-20
  • 通讯作者: 张博

Preparation of Uniform-sized Gelatin Microspheres Loading Ferrous Sulfate by Premix Membrane Emulsification

ZHANG Bo WANG Ying WANG Qi-bao YANG Ting-yuan ZHANG Gui-feng WANG Lian-yan,   

  1. China University of Ming & Technology China University of Ming & Technology College of Chemical and Environmental Engineering,China University of Mining and Technology State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, CAS State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences
  • Received:2015-07-07 Revised:2015-08-07 Online:2015-10-20 Published:2015-10-20
  • Contact: ZHANG Bo

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被引次数

1

摘要： 采用快速膜乳化技术，以大豆油为油相、葡萄糖为固化剂，制备均一载硫酸亚铁明胶微球，考察了制备参数对明胶微球形貌和均一性的影响. 结果表明，优化的制备参数为明胶溶液浓度0.200 g/mL、乳化剂浓度0.07 g/mL、初乳均质转速10000 r/min、固化反应时间20 min. 在该条件下制备了球形圆整、平均粒径为50 μm的均一载FeSO4明胶微球，FeSO4包埋率达44.12%，Fe2+含量为60.8%.

关键词: 快速膜乳化, 明胶微球, 大豆油, 葡萄糖, 硫酸亚铁

Abstract: Ferrous sulfate-loaded gelatin microspheres were prepared by premix membrane emulsification, using soybean oil with food grade as oil phase and glucose as solidification agent, the effects of preparation conditions on microspheres morphology and size distribution examined, and the optimal conditions of gelatin microspheres obtained. The results showed that under the optimal concentrations of gelatin solution and emulsifier at 0.200 and 0.07 g/mL respectively, homogenizing rate 10000 r/min, and solidification time 20 min, the gelatin microspheres loading ferrous sulfate were successfully prepared. The microspheres were spherical and uniform in size, and their mean size was 50 μm and encapsulation efficiency of ferrous sulfate 44.12%, containing 60.8% ferrous ion.

Key words: premix membrane emulsification, gelatin microsphere, bean oil, glucose, ferrous sulfate

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