Model and Numerical Analysis of Dynamic Distributions of Dissolved Oxygen Concentrations in the Reactor of Bioartificial Liver Support System
LIU Jian-feng SONG Tao LI Rui-yu LI Ming LIU Guo-qiang
Institute of Electrical Engineering, Chinese Academy of Science (1. Institute of Electrical Engineering, Chinese Academy of Science Institute of Electrical Engineering, Chinese Academy of Science (1. Institute of Electrical Engineering, Chinese Academy of Science
Abstract：Based on the analysis of gas-liquid mass transfer and liquid flow in the reactor of bioartificial liver support system, and comprehensive consideration of the configuration and the actual needs of the reactor, the mathematic mechanism model of dynamic distribution of dissolved oxygen concentrations in the reactor was build up based on one-dimensional axial diffusion model. The equations set was solved by finite difference method and the effects of conditions, such as flow rate, oxygen mass transfer coefficient and oxygen consumption rate on distributions of dissolved oxygen concentration were investigated. The results show that the optimal parameters in the reactor are liquid flow rate 0.55 mm/s, mass transfer coefficient 0.31 s-1, and diffusion coefficient 0.02 mm2/s. Based on the experimental data, the model is proved and the average calculation error can be limited in ±5%. The results are of reference to the optimum design of the reactor in bioartificial liver support system, and this model provides a reliable theoretical basis.
刘剑峰 宋涛 李睿瑜 李明 刘国强. 人工肝生物反应器中溶解氧浓度动态分布的模型与数值分析[J]. , 2008, 8(3): 417-424.
LIU Jian-feng SONG Tao LI Rui-yu LI Ming LIU Guo-qiang. Model and Numerical Analysis of Dynamic Distributions of Dissolved Oxygen Concentrations in the Reactor of Bioartificial Liver Support System. , 2008, 8(3): 417-424.
2008, Vol. 8 
