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›› 2014, Vol. 14 ›› Issue (1): 139-144.

• 生化工程专栏 • 上一篇    下一篇

促孕原位凝胶灌注液的制备及其体外释放度

卢朝成 符华林 周涛 张艳丽 刘梦娇 金超 曹航 罗莉   

  1. 四川农业大学动物医学院 四川农业大学 动物医学院 华北电力大学核热工安全和标准化研究所 四川农业大学 动物医学院 四川农业大学 动物医学院 动物疫病与人类健康四川省重点实验室 四川农业大学 动物医学院 四川农业大学 动物医学院 四川农业大学 动物医学院
  • 收稿日期:2013-10-29 修回日期:2013-12-09 出版日期:2014-02-20 发布日期:2014-02-20
  • 通讯作者: 符华林

Preparation of Fertility-promoting Intrauterine Infusion in situ Gel and Its in vitro Release

LU Chao-cheng FU Hua-lin ZHOU Tao ZHANG Yan-li LIU Meng-jiao JIN Chao CAO Hang LUO Li   

  1. College of Veterinary Medicine, Sichuan Agricultural University College of Veterinary Medicine, Sichuan Agricultural University Institute of Nuclear Thermal -Hydraulic Safety and Standardization, North China Electricity Power University College of Veterinary Medicine, Sichuan Agricultural University College of Veterinary Medicine, Si chuan Agricultural University College of Veterinary Medicine, Sichuan Agricultural University College of Veterinary Medicine, Sichuan Agricultural University College of Veterinary Medicine, Sichuan Agricultural University
  • Received:2013-10-29 Revised:2013-12-09 Online:2014-02-20 Published:2014-02-20
  • Contact: FU Hua-lin

摘要: 以泊洛沙姆407 (P407)和188 (P188)为载体材料,采用冷溶法将促孕灌注液制成原位凝胶,考察了P407和P188浓度、羟丙基甲基纤维素浓度(HPMC)、海藻酸钠浓度及促孕灌注液对胶凝温度的影响,研究了体外溶蚀、体外释药特性. 结果表明,P407浓度为18%(w)、P188浓度为7.5%(w)、HPMC浓度为0.3%(w)时,凝胶平均胶凝温度为27.9℃, 6 h内平均体外累积溶蚀度和药物累积释放度分别为92.11%和95.42%,凝胶中的药物成分主要通过溶蚀方式释放,药物释放符合零级释药方程.

关键词: 促孕灌注液, 原位凝胶, 胶凝温度, 体外溶蚀, 体外释放, 淫羊藿苷

Abstract: Fertility-promoting intrauterine infusion in situ gel (FPG) was prepared by cold soluble method with Poloxamer 407 (P407) and Poloxamer 188 (P188). The effects of concentrations of P407, P188, hydroxy propyl methyl cellulose (HPMC) and sodium alginate on gelation temperature were studied, the gelation temperature of in situ gel before and after addition of fertility-promoting intrauterine infusion liquid and release behavior in vitro were investigated. The results showed that the average gelation temperature of FPG was 27.9℃ when the concentrations of P407, P188 and HPMC were 18%(w), 7.5%(w) and 0.3%(w). Average accumulated loss rate of gel and accumulated release rate of drug were 92.11% and 95.42% in 6 h. The drug in the gel was released by the gel erosion, and the release profiles accorded to zero order equation.

Key words: fertility-promoting intrauterine infusion liquid, in situ gel, gelation temperature, in vitro dissolution, in vitro release, icariin

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