两亲性刺突微球的制备及性能表征

doi:10.12034/j.issn.1009-606X.216372

过程工程学报 ›› 2017, Vol. 17 ›› Issue (4): 821-826.DOI: 10.12034/j.issn.1009-606X.216372

两亲性刺突微球的制备及性能表征

胡琳琳^1，2，韦祎²^*，徐玉松¹，居殿春¹，马光辉²

1. 江苏科技大学冶金与材料工程学院，江苏张家港 215600；2. 中国科学院过程工程研究所生化工程国家重点实验室，北京 100190

收稿日期:2016-12-09 修回日期:2017-01-19 出版日期:2017-08-20 发布日期:2017-08-16
通讯作者: 韦祎 ywei@ipe.ac.cn
基金资助:
细胞转运肽修饰刺突状纳微球用于生长激素口服给药的研究

Preparation and Properties of Amphipathy Furcella Microspheres

Linlin HU^1,2, Yi WEI²?, Yusong XU¹, Dianchun JU¹, Guanghui MA²

1. Sch. Metall. & Mater. Eng., Jiangsu University of Science and Technology, Zhangjiagang, Jiangsu 215600, China;
2. National Key Lab. Biochem. Eng., Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China

Received:2016-12-09 Revised:2017-01-19 Online:2017-08-20 Published:2017-08-16
Supported by:
Modified spike nano/microspheres with cell transport peptide for oral delivery of growth hormone

摘要/Abstract

摘要： 以两亲性聚合物聚乙二醇-聚(乳酸-乙醇酸)共聚物(mPEG-PLGA)为材料，采用复乳法结合溶剂挥发法制备mPEG-PLGA刺突微球，用其吸附蛋白多肽类药物.考察了膜材组份比、LA/GA摩尔比、内水相与油相体积比、油相与外水相体积比、固化条件等因素对微球的形貌结构及包埋率的影响. 结果表明，优化的制备条件为：膜材组份比1/19，LA/GA摩尔比50/50，W1/O体积比0.2/1，O/W2体积比1/10，固化搅拌速率500 rpm. 该条件下，微球刺突结构特征明显，包埋率较高，达到70%以上，且比表面积是普通光滑微球的14倍.

关键词: mPEG-PLGA, 刺突微球, 影响因素, 比表面积

Abstract: Furcella methoxy poly(ethylene glycol-L-lactic-co-glycolic acid) (mPEG-PLGA) microspheres were successfully prepared by double emulsion method with solvent evaporate method. The effects of polymer components,LA/GA molar ratio,volume ratio of internal water phase to oil phase,volume ratio of oil phase to external water phase and solidification rate on morphology and encapsulation of microspheres were investigated. The results showed that the microspheres with furcella morphology were prepared by the condition of 1/19 polymer components,50/50 LA/GA molar ratio,0.2/1 volume ratio of internal water phase to oil phase,1/10 volume ratio of oil phase to external water phase and 500 rpm solidification rate. In addition, its encapsulation efficiency is as high as 70%, specifica surface area of furcella microspheres is as fourteen times as the smooth microspheres.

Key words: methoxy poly(ethylene glycol-L-lactic-co-glycolic acid), furcella microspheres, influence factor, specific surface area

胡琳琳韦祎徐玉松居殿春马光辉. 两亲性刺突微球的制备及性能表征[J]. 过程工程学报, 2017, 17(4): 821-826.

Linlin HU Yi WEI Yusong XU Dianchun JU Guanghui MA. Preparation and Properties of Amphipathy Furcella Microspheres[J]. Chin. J. Process Eng., 2017, 17(4): 821-826.

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两亲性刺突微球的制备及性能表征

Preparation and Properties of Amphipathy Furcella Microspheres

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