基于纳米氢氧化铝颗粒的Pickering乳液制备

doi:10.12034/j.issn.1009-606X.219138

过程工程学报 ›› 2019, Vol. 19 ›› Issue (6): 1220-1227.DOI: 10.12034/j.issn.1009-606X.219138

基于纳米氢氧化铝颗粒的Pickering乳液制备

吴楠^1,2，吴颉^2*，苗春宇²，马光辉^1,2，安文琪³

1. 中国科学院大学化学工程学院，北京 100049 2. 中国科学院过程工程研究所生化工程国家重点实验室，北京 100190 3. 华兰生物工程股份有限公司，河南新乡 453003

收稿日期:2019-02-28 修回日期:2019-03-26 出版日期:2019-12-22 发布日期:2019-12-22
通讯作者: 吴颉 wujie@ipe.ac.cn
基金资助:
中国科学院国际合作局国际伙伴计划项目

Preparation of Pickering emulsion based on alumina hydroxide nanoparticles

Nan WU^1,2, Jie WU^2*, Chunyu MIAO², Guanghui MA^1,2, Wenqi AN ³

1. School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, China 2. National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China 3. Hualan Biological Engineering Co., Ltd., Xinxiang, Henan 453003, China

Received:2019-02-28 Revised:2019-03-26 Online:2019-12-22 Published:2019-12-22
Contact: WU Jie wujie@ipe.ac.cn

摘要/Abstract

摘要： 以异丙醇铝为原料，采用醇盐水解?水热法制备勃姆石型纳米氢氧化铝颗粒，优化制备条件；以所制颗粒为稳定剂、角鲨烯为油相，通过超声破碎法制备Pickering乳液，考察了颗粒浓度、水相成分、超声时间及功率对Pickering乳液粒径及稳定性的影响。结果表明，水热温度200℃、水热时间2 h条件下，可制得结晶度高且均一的勃姆石型纳米氢氧化铝颗粒，平均粒径为55.70?9.20 nm，多分散性指数(PDI)为0.187?0.011；所制Pickering乳液平均粒径为1870?55 nm，PDI=0.120?0.010，可在室温下稳定储存120 d以上，且生物相容性良好，有望应用于生物医药领域。

关键词: 纳米氢氧化铝, 水解-水热法, 勃姆石, Pickering乳液, 储存稳定性

Abstract: Pickering emulsion is a new type of emulsion stabilized by solid particles instead of traditional organic surfactants. Compared to the traditional surfactant-stabilized emulsion, Pickering emulsion has the advantages of strong interfacial stability, regeneration, low toxicity and low cost, and has broad application value in the fields of food, medicine and cosmetics. The size of solid particle for stabilizing Pickering emulsion is in the nanometer range. The particles used to prepare Pickering emulsion are generally inorganic particles and polymer particles, most of which are not biocompatible or easily degradable. It is important to choose materials that have both good biocompatibility and stability. In this work, the boehmite-type aluminium hydroxide nanoparticles were prepared from aluminum isopropoxide by hydrolysis?hydrothermal method. Pickering emulsion was prepared by using boehmite-type aluminium hydroxide nanoparticles as stabilizer and squalene as oil phase. The effects of preparation conditions on size distribution and stability of Pickering emulsion were examined, including the concentration of nanoparticles, aqueous phase and dispersion condition. The results showed that two main factors affected the formation of nanoparticles were hydrothermal temperature and time. When the hydrothermal temperature was set to 200℃ for 2 h, the boehmite-type aluminium hydroxide nanoparticles were spherical with good dispersibility, uniform size distribution and high crystallinity. The average size of boehmite-type aluminium hydroxide nanoparticles was 55.70?9.20 nm and the polydispersity index was 0.187?0.011. The average size of Pickering emulsion was 1870?55 nm and the polydispersity index was 0.120?0.010. The Pickering emulsion could be stored stably at room temperature for more than 120 d. Based on this study, Pickering emulsion with uniform size distribution and good dispersibility was prepared, which provided a new material for biomedical area.

Key words: aluminium hydroxide nanoparticle, hydrolysis-hydrothermal methods, boehmite, Pickering emulsion, storage stability

吴楠吴颉苗春宇马光辉安文琪. 基于纳米氢氧化铝颗粒的Pickering乳液制备[J]. 过程工程学报, 2019, 19(6): 1220-1227.

Nan WU Jie WU Chunyu MIAO Guanghui MA Wenqi AN. Preparation of Pickering emulsion based on alumina hydroxide nanoparticles[J]. Chin. J. Process Eng., 2019, 19(6): 1220-1227.

参考文献

[1]Zhang L, Zhang F, Wang Y S, et al.Magnetic colloidosomes fabricated by Fe3O4–SiO2 hetero-nanorods[J].Soft. Mater., 2011, 7(16):7375-7381
[2]Shen X, Xu C, Uddin K A, et al.Molecular recognition with colloidosomes enabled by imprinted polymer nanoparticles and fluorogenic boronic acid[J].J. Mater. Chem., 2013, 1(36):4612-4618
[3]Shilpi S, Jain A, Gupta Y, et al.Colloidosomes: an emerging vesicular system in drug delivery[J].Crit. Rev. Ther. Drug., 2007, 24(4):361-391
[4] Binks B P.Wetting:theory and experiment [J]. Current Opinion in Colloid & Interface Science. 2001, 6(1): 17-21.[J].Current Opinion in Colloid & Interface Science., 2011, 6(1):17-21
[5] Binks B P, Whitby C P.Silica particle-stabilized emulsions of silicone oil and water:Aspects of emulsification [J]. Langmuir. 2004, 20(4):1130-1137.[J].Langmuir, 2004, 20(4):1130-1137
[6] Jiang J, Zhu Y, Cui Z, et al.Switchable pickering emulsions stabilized by silica nanoparticles hydrophobized in situ with a switchable surfactant [J]. Angewandte Chemie International Edition. 2013, 125(47): 12599-12602.[J].Angewandte Chemie International Edition, 2013, 125(47):12599-12602
[7] Binks B P, Whitby C P.Nanoparticle silica-stabilised oil-in-water emulsions:improving emulsion stability [J]. Colloids and Surfaces A:Physicochemical and Engineering Aspects. 2005, 253(1-3):105-115.[J].Colloids and Surfaces A:Physicochemical and Engineering Aspects, 2005, 253(1-3):105-115
[8] Binks B P, Philip J, Rodrigues J A.Inversion of silisa-stabilized emulsions induced by particle concentration [J]. Langmuir. 2005, 21(8):3296-3302.[J].Langmuir, 2005, 21(8):3296-3302
[9] Shen M, Resasco D E.Emulsions stabilized by carbon nanotube-silica nanohybrids [J]. Langmuir. 2009, 25(18):10843-10851.[J].Langmuir, 2009, 25(18):10843-10851
[10] Lagaly G, Reese M, Abend S.Smectites as colloidal stabilizers of emulsions I.Preparation and properties of emulsions with smectites and nonionic surfactant [J]. Applied Clay Science. 1999, 14(1):83-103.[J].Applied Clay Science, 1999, 14(1):83-103
[11] Binks B P, Lumsdon S.Stability of oil-in-water emulsions stabilized by silica particles [J]. Physical Chemistry Chemical Physics. 1999, 1(12):3007-3016.[J].Physical Chemistry Chemical Physics, 1999, 1(12):3007-3016
[12] Kim J, Cote L J, Kim F, et al.Graphene Oxide Sheets at Interfaces [J]. Journal of the American Chemical Society. 2010, 132(23):8180-8186.[J].Journal of the American Chemical Society, 2010, 132(23):8180-8186
[13] He Y, Wu F, Sun X, et al.Factors that Affect Pickering Emulsions Stabilized by Graphene Oxide [J]. Acs Applied Materials & Interfaces. 2013, 5(11): 4843-4855.[J].Acs Applied Materials & Interfaces, 2013, 5(11):4843-4855
[14]Song X, Yang Y, Liu J, et al.PS colloidal particles stabilized by graphene oxide[J].Langmuir, 2011, 27(3):1186-1191
[15] Nan F F, Wu J, Qi F, et al.Uniform chitosan-coated alginate particles as emulsifiers for preparation of stable Pickering emulsions with stimulus dependence [J]. Colloids and Surfaces A: Physicochem. Eng. Aspects, 2014, 456:246-252.[J].Colloids and Surfaces A: Physicochem, 2014, 456:246-252
[16] Qi F, Wu J, Sun G Q, et al.Systematic studies of Pickering emulsions stabilized by uniform-sized PLGA particles: preparation and stabilization mechanism [J]. Journal of Material Chemistry B. 2014, 2(43):7605-7611.[J].Journal of Material Chemistry B. 2014, 2(43):7605-7611., 2014, 2(43):7605-7611
[17]Bielinska A U, O' Konek J J, Janczak K W, et al.Immunomodulation of TH2 biased immunity with mucosal administration of nanoemulsion adjuvant[J].Vaccine, 2016, 34(34):4017-4024
[18]Kuroda E, Coban C, Ishiii K J, et al.Particulate adjuvant and innate immunity: past achievements,present findings,and future propects[J].Int. Rev. Immunol., 2013, 32(2):209-220
[19]Joshi M D, Unger W J, Storm G, et al.Targeting tumor antigens to dendritic cells using particulate carriers[J].J. Control. Release, 2012, 161(1):25-37
[20]Zhou H Y, Wang G C, Li X F, et al.Alumina-encapsulated vaccine formulation with improved thermostability and immunogenicity[J].Chem. Commun., 2016, 52(38):6447-6450
[21]Ma M G, Zhu Y J, Xu Z J.A new route to synthesis of γ-alumina nanorods[J].Mater. Lett., 2007, 61(8-9):1812-1815
[22]Yu Z Q, Wang C X, Gu X T, et al.Photoluminescent properties of boehmite whisker prepared by sol-gel process[J].J. Lumin., 2004, 106(2):153-157
[23]李慧，胡燚，苏国东，等.合成方法对γ-催化剂乙醇脱水性能的影响[J].石油化工, 2009, 38(4):373-378
[24]Li H, HU Y, Su G D, et al.Effect of Preparation Method for γ-Al2O3 Catalyst on Dehydration of Ethanol[J].Petrochemical Technology, 2009, 38(4):373-378
[25]吴祖燊，李齐春，戴品中.异丙醇铝气相燃烧法制备纳米氧化铝的实验研究[J].精细与专用化学品, 2011, 19(8):26-29
[26]Wu Z S, Li Q C, Dai P Z.Study on preparation of nano-alumina by aluminum isopropoxide combustion[J].Fine and Specialty Chemicals, 2011, 19(8):26-29
[27]Ginberg E E, Saradzhev V V, Levin I, et al.Preparation of fine alumina powders by hydrolysis of aluminum isopropylate[J].Russ. J. Appl. Chem., 2002, 75(2):245-247
[28]Zhang L, Cheng B, Shi W S, et al.In-situ electrochemical synthesis of 1-dimensional alumina nanostructures[J].J. Mater. Chem., 2005, 15(46):4889-4893
[29]张璐，姚素薇，张卫国，等.氧化铝纳米线的制备及其形成机理[J].物理化学学报, 2005, 21(11):1254-1258
[30]Zhang L, Yao S W, Zhang W G, et al.Preparation and Formation Mechanism of Alumina Nanowires[J].Acta Physico-Chimica Sinica, 2005, 21(11):1254-1258
[31]张彩霞，罗序燕，吴速英.微乳法制备氧化铝纳米粉体的研究[J].无机盐工业, 2006, 38(10):26-28
[32]Zhang C X, Luo X Y, Wu S Y.Research on the preparation of Al2O3 nano-powder by microemulsion methed[J].Inorganic Chemicals Industry, 2006, 38(10):26-28
[33]Ghosh S，Naskar M K.Synthesis of mesoporous γ-alumina nanorods using a double surfactant system by reverse microemulsion process[J].RSC Advance, 2013, 3(13):4207-4211
[34] 江琦，雷蕾.醇盐水解-水热法制备高结晶度纳米氢氧化铝 [J].材料导报. 2008, 22(z3):23-25.[J].材料导报. 2008, 22(z3):23-25., 2008, 22(z3):23-25
[35]Jing Q, Lei L.Preparation of Nano Aluminium Hydroxide with High Crystallinity from Aluminium Isopropoxide Through a Hydrolysis-Hydrothermal Process [J].Materials Review. 2008, 22(z3):23-25.[J].Materials Review, 2008, 22(z3):23-25
[36]Li Y Y, Liu J P, Jia Z J.Fabrication of boehmite AlOOH nanofibers by a simple hydrothermal process[J].Mater. Lett., 2006, 60(29-30):3586-3590
[37]Mishra D, Anand S, Panda R K.Effect of anions during hydrothermal preparation of boethmites[J].Mater. Lett., 2002, 53(3):133-137
[38]李瑞，王青山.生物材料生物相容性的评价方法和发展趋势[J].中国组织工程研究与临床康复, 2011, 15(29):5471-5474
[39]Li R, Wang Q S.Evaluated methods and developmental trend of biocompatibility of biomaterials[J].Journal of clinical rehabilitative tissue engineering research, 2011, 15(29):5471-5474

基于纳米氢氧化铝颗粒的Pickering乳液制备

Preparation of Pickering emulsion based on alumina hydroxide nanoparticles

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 4

编辑推荐

Metrics

[1]	陈秋汀吴楠吴颉王晓军马光辉. Al-Pickering乳液提高口蹄疫疫苗热稳定性的应用[J]. 过程工程学报, 2022, 22(4): 469-477.
[2]	包谢茹吴颉马光辉. 用于细菌生物膜感染治疗的Pickering乳液制备[J]. 过程工程学报, 2021, 21(5): 594-600.
[3]	屈艳玲吴颉马光辉. 基于纤维素纳米晶稳定的亚微米Pickering乳液制备[J]. 过程工程学报, 2021, 21(4): 454-462.
[4]	刘有智;李裕;柳来栓. 改性纳米Al(OH)3粉体的制备[J]. , 2003, 3(1): 0-0.