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›› 2008, Vol. 8 ›› Issue (1): 152-156.

• 材料工程专栏 • 上一篇    下一篇

以ZnO微球为模板制备硫酸葡聚糖/鱼精蛋白胶囊及其缓释行为

杨晓玲,乔擎宇,曹慧敏,朱以华   

  1. 华东理工大学超细材料制备与应用教育部重点实验室
  • 出版日期:2008-02-20 发布日期:2008-02-20

Preparation of Multilayer Dextran Sulfate/Protamine Capsules Templated on ZnO Microspheres and Their Drug Controlled Release Behavior

YANG Xiao-ling,QIAO Qin-yu,CAO Hui-min,ZHU Yi-hua   

  1. Key Laboratory for Ultrafine Materials of Ministry of Education ECUST
  • Online:2008-02-20 Published:2008-02-20

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被引次数

7

摘要： 以ZnO微球为模板，利用层层自组装的方法制备了壁材为鱼精蛋白(PRM)和硫酸葡聚糖(DXS)的生物可降解聚电解质胶囊. ZnO微球呈良好的单分散性，具有5 nm以上的中孔，装载荧光素后生成荧光微球. 在ZnO微球外交替吸附鱼精蛋白和硫酸葡聚糖，制得核-壳型ZnO/(DXS/PRM)8复合微球；采用稀HAC溶液去除ZnO模板后，可生成(DXS/PRM)8胶囊. 以水溶性多柔米星药物分子作为目标物，研究了该胶囊的载药和释放行为. 结果显示，该(DXS/PRM)8胶囊对多柔米星药物分子具有明显的缓释性.

关键词: 层层自组装, 氧化锌微球, 鱼精蛋白, 硫酸葡聚糖, 载药

Abstract: Ultrathin polyelectrolyte capsules were produced by layer-by-layer assembling of biodegradable polyelectrolytes, dextran sulfate (DXS) and protamine (PRM), on ZnO microspheres followed by the cores decomposition with dilute HAC solution. ZnO microspheres were well mono-dispersed and had around 5 nm intermediate size pores, which could be used as fluorescein delivery. PRM and DXS formed regular growing stable multilayers on ZnO microspheres, thus formed ZnO/(DXS/PRM)8 core-shell microspheres. After removal of ZnO template, (DXS/PRM)8 capsules were fabricated. The loaded drug amount and controlled release behavior of hollow capsules were examined in the sample of dexorubicin hydrochloride (DOX). The result shows that (DXS/PRM)8 demonstates obvious controlled release of DOX drug.

Key words: ayer-by-layer self-assembly, ZnO microspheres, protamine, dextran sulfate, drug carrier