Abstract: Porous hollow silica nanoparticles (PHSNs) with O.D. of ~90 nm and a wall thickness of ~15 nm were prepared by using inorganic CaCO3 templates. The produced porous hollow silica nanoparticles were employed as a novel adsorption carrier to study the adsorption behavior of avermectin, which was used as a model pesticide, in supercritical carbon dioxide. Through orthogonally designed experiments, the optimal adsorption conditions of porous hollow silica nanoparticles for avermectin were obtained, which correspond to the adsorption pressure of 50 MPa, adsorption temperature of 40℃, adsorption time of 6 h and cosolvent volume of 5 mL.

Key words: porous hollow silica nanoparticles, supercritical carbon dioxide, orthogonal test, avermectin

摘要： 以本实验室合成的空心多孔SiO2纳米球作为新型吸附介质，以阿维菌素为模型吸附药物，采用正交实验法对空心多孔SiO2纳米球的吸附参数进行了优化. 研究结果表明，利用无机-有机双模板法制备出的空心多孔SiO2纳米球具有很强的吸附能力，采用超临界流体技术能有效地把模型药物阿维菌素吸附到多孔空心结构中，吸附量可达61.5%. 在压力、温度、吸附时间、共溶剂用量4个影响吸附量的因素中，压力和共溶剂的影响具有显著性，吸附时间的影响较显著，温度的影响不显著. 最佳的吸附条件为：压力50 MPa，温度40℃，时间6 h，共溶剂(丙酮)添加量5 mL.

关键词: 空心多孔SiO2纳米球, 超临界流体, 正交实验, 阿维菌素