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›› 2012, Vol. 12 ›› Issue (5): 760-764.

• 流动与传递 • Previous Articles     Next Articles

Preparation of Lactose Particles Using Side Spray Technology in a Fluidized Bed

ZONG Rui-xia JING Qiu-fang MA Xiao-si REN Fu-zheng   

  1. Shanghai Key Laboratory of New Drug Design, East China university of science and technology Shanghai Key Laboratory of New Drug Design, East China university of science and technology Shanghai Key Laboratory of New Drug Design, East China university of science and technology Shanghai Key Laboratory of New Drug Design, East China university of science and technology
  • Received:2012-08-10 Revised:2012-10-08 Online:2012-10-20 Published:2012-10-20
  • Contact: REN Fu-zheng

流化床侧喷技术制备乳糖颗粒的工艺

宗瑞霞 景秋芳 马小思 任福正   

  1. 华东理工大学药学院上海市新药设计重点实验室 华东理工大学药学院上海市新药设计重点实验室 华东理工大学药学院上海市新药设计重点实验室 华东理工大学药学院上海市新药设计重点实验室
  • 通讯作者: 任福正

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Abstract: Preparation of lactose particles in a fluidized bed was investigated using side spray technology. The particle size distribution and flowability were selected to evaluate the granulation with hydroxypropyl methylcellulose K4M as binding agent. Over 85%(j) of the particles were in the range of 200~355 mm when optimum formulation and process parameters were chosen, including the concentration of binding agent 1.5%(w), its mass increment 2%, spray rate 14~18 g/min, and atomization pressure 1.5′105 Pa. The slope of repose of granules (<34o) and degree of compression (<10%) showed the good flowability of lactose particles. The particles had a spherical shape, when observed under an optical microscope. The preparation process was very stable and had a good repeatability.

Key words: fluidized bed, side spray, lactose, granulation, process parameter

摘要： 采用流化床侧喷制粒技术，以羟丙基甲基纤维素K4M为粘合剂制备乳糖颗粒. 以颗粒粒径分布与流动性为主要评价指标，得到优化的制备参数为：粘合剂浓度1.5%，用量2.0%，喷液速度14~18 g/min，雾化压力1.5′105 Pa. 200~355 mm的目标粒子收率在85%以上，颗粒休止角均小于34o，压缩度均小于10%，流动性好，光学显微镜下颗粒呈类球形. 制备工艺稳定，重现性好.

关键词: 流化床, 侧喷技术, 乳糖, 制粒, 工艺参数