Progress of Single-dose Vaccine Using Nanoparticle-based Delivery System

doi:10.12034/j.issn.1009-606X.217101

Abstract

Abstract: Vaccination is one of the most effective methods for the prevention and treatment of infectious diseases. The scientists have focused on the research and development of vaccines for many years. Traditional vaccines usually require immunization for many times to achieve good immune response. Many people have not received timely immunization in remote area, which result in that there are over 100 million children each year around the world to be infected with disease or even death. Scientists have tried to develop novel single-dose vaccine basing on study of sustained and controlled release delivery systems in recent years. The successful development of single-dose vaccine will help to improve the vaccination rate and realize effective prevention and control of infectious diseases. This review elaborates the development process of single-dose vaccination, properties and regulation of single-dose vaccination based on biodegradable nanoparticles, potential strategies for the single-dose vaccination.

Key words: single-dose vaccine, nanoparticles, immune response, the regulation of antigen release

摘要： 接种疫苗是防控传染病的有效手段之一，多年来，人们一直致力于疫苗的研究与开发. 传统疫苗通常需多次免疫才能达到良好的免疫效果，偏远地区漏种情况严重，导致全球每年约有1亿儿童因不能按时接种疫苗而感染发病甚至死亡. 近年来，研究者们通过对缓、控释递送系统的研究，开发单剂疫苗，以提高疫苗接种覆盖率、有效防控传染病. 本工作主要对单剂疫苗的历史发展过程、基于可生物降解纳微颗粒的单剂疫苗的性质与调控、纳微颗粒单剂疫苗面临的挑战进行概述.

关键词: 单次免疫, 纳微颗粒, 免疫效应, 抗原释放调控

Meiyang YANG Lianyan WANG Tingyuan YANG Xueying YAN?. Progress of Single-dose Vaccine Using Nanoparticle-based Delivery System[J]. Chin. J. Process Eng., 2017, 17(5): 893-902.

杨美洋王连艳杨婷媛阎雪莹. 基于可生物降解纳微颗粒的单剂免疫疫苗研究进展[J]. 过程工程学报, 2017, 17(5): 893-902.

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