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›› 2006, Vol. 6 ›› Issue (4): 674-682.

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多糖免疫调节和抗肿瘤研究进展

王统一,赵兵,王玉春   

  1. 中国科学院过程工程研究所生化工程国家重点实验室
  • 出版日期:2006-08-20 发布日期:2006-08-20

Research Advances in Immunomodulation and Antitumor Activity of Polysaccharides

WANG Tong-yi,ZHAO Bing,WANG Yu-chun   

  1. State Key Laboratory of Biochemical Engineering, Institute of Process Engineering
  • Online:2006-08-20 Published:2006-08-20

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被引次数

136

摘要： 增强免疫和抗肿瘤活性是多糖重要的生物活性. 研究表明，多糖可以通过增强免疫细胞活性、激活细胞因子的分泌、诱导生成抗体及激活补体系统等作用增强机体免疫功能. 多糖的抗肿瘤途径主要为抑制肿瘤细胞的生长、蛋白质及核酸的合成，诱导肿瘤细胞凋亡、影响癌基因的表达及改变肿瘤细胞膜的生长特性. 本文介绍了近年来多糖免疫调节和抗肿瘤研究方面的进展.

关键词: 多糖, 免疫调节, 抗肿瘤, 细胞凋亡

Abstract: Enhancing immunity and antitumor activity is the important biological activity of polysaccharide. Studies showed that it enhanced immunity through improving the activity of immunocyte, activising the secretion of cell factor, inducing the production of antibody and activising the complementary system, etc. The antitumor ways of polysaccharide mainly were inhibiting the growth of cancer cells and the synthesis of protein and nuclear acid in the cells, inducing apoptosis, affecting the expression of cancer gene and changing the growing specialities of the cancer cell membrane. In this review, research advances in the field of immunomodulation and antitumor activity of polysaccharides in recent years were briefly summarized and analysed.

Key words: polysaccharide, immunomodulation, antitumor, apoptosis