欢迎访问过程工程学报, 今天是

过程工程学报 ›› 2022, Vol. 22 ›› Issue (9): 1232-1243.DOI: 10.12034/j.issn.1009-606X.221329

• 研究论文 • 上一篇    下一篇

颗粒形状对包衣设备内药片颗粒运动特性影响的数值模拟

熊桂龙1,2*， 苏文康1,2， 王安奇1,2， 王一泽1,2
  

  1. 1. 南昌大学资源环境与化工学院，江西 南昌 330031 2. 南昌大学鄱阳湖环境与资源利用教育部重点实验室，江西 南昌 330031
  • 收稿日期:2021-10-18 修回日期:2021-12-09 出版日期:2022-09-28 发布日期:2022-10-09
  • 通讯作者: 熊桂龙 jcijxcn@163.com
  • 作者简介:熊桂龙(1981-)，男，江西省丰城市人，博士，副教授，能源与动力工程专业，E-mail: jcijxcn@163.com.
  • 基金资助:
    水汽相变耦合撞击流作用下燃煤电站PM2.5长大脱除的研究;基于撞击流与化学团聚的燃煤电站PM2.5脱除研究

Numerical simulation of effect of particle shape on tablet particles motion characteristics in a pan coater

Guilong XIONG1,2*,  Wenkang SU1,2,  Anqi WANG1,2,  Yize WANG1,2   

  1. 1. School of Resources Environmental and Chemical Engineering, Nanchang University, Nanchang, Jiangxi 330031, China 2. Key Laboratory of Poyang Lake Environment and Resource Utilization, Ministry of Education, Nanchang University, Nanchang, Jiangxi 330031, China
  • Received:2021-10-18 Revised:2021-12-09 Online:2022-09-28 Published:2022-10-09
  • Contact: Guilong Xiong jcijxcn@163.com

RichHTML

PDF

摘要： 为研究颗粒形状对包衣设备内药片颗粒运动特性的影响，基于离散单元法及自行编写的喷雾区颗粒检测算法，采用数值模拟的方法对五种不同形状(棒状、长椭球、扁椭球、双凸形和球形)的药片颗粒在包衣设备内的运动行为规律进行了研究。分析了颗粒形状对颗粒系统的能量、床面颗粒平动速度、颗粒温度及颗粒流在喷雾区域停留时间的分布及其相对标准差的影响。结果表明，颗粒形状对颗粒的平均动能、颗粒床面速度、颗粒温度、喷雾区域停留时间分布及颗粒间包衣均匀性有重要影响。除双凸形颗粒系统外，对于其他四种形状的颗粒系统，随着颗粒球形度增大，颗粒系统具有的动能、床面速度和颗粒温度均呈减小趋势。除棒状颗粒系统外，对于其余四种形状的颗粒系统，随着颗粒球形度增大，颗粒系统在包衣喷雾区域内平均停留时间减小，平均停留时间的相对标准差增大，包衣均匀性变差。与球形颗粒系统相比，非球形颗粒系统的包衣均匀性更好；药片颗粒形状对包衣设备内颗粒运动特性及颗粒之间的包衣均匀性有重要影响。

关键词: 颗粒形状, 包衣, 数值模拟, 颗粒流, 速度波动, 停留时间分布

Abstract: The knowledge of the particle shape and motion characteristics in a pan coater is critical to optimize the design and operation of coating equipment. To research the influence of tablet shape on the motion characteristics in a coating device, which based on discrete element method and spray zone approach, the motion characteristics of tablet particles with five shapes including rod, long ellipsoid, oblate ellipsoid, biconvex and spherical was investigated by numerical simulation. Inter-tablet variability of film coating was a critical issue in the production of solid oral dosage forms. Residence time distribution and it's relative standard deviation was developed to characterize the coating process throughout the coating vessel. The effect of tablet shape on energy of granular system, surface particles translational velocity, granular temperatures, residence time distribution and it's relative standard deviation was investigated systematically. The results showed that tablet shape significantly affected the kinetic energy of granular system, particle translational velocity, granular temperatures, residence time distribution and inter-tablet coating variability. Except for the biconvex granular system, the kinetic energy, bed translational velocity and granular temperatures of the other four kinds of granular system decreased with the increasing sphericity. Residence time distribution of the granular system gradually became normal. Weight gain mass coating variability (CVm) was to be inversely proportional to the square root of coating time and in good agreement with the Chang and Leoni experimental results. Except for the rod-shaped granular system, there was a decrease in the average residence time of the granular system in the coating spray area, an increase in the relative standard deviation of the average residence time with the increasing sphericity. Meanwhile, the inter-tablet coating variability also deteriorated. Compared with the spherical granular system, the inter-tablet coating variability of non spherical granular system showed a better behavior.

Key words: particle shape, coating, numerical simulation, granular flow, velocity fluctuation, residence time distribution