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›› 2009, Vol. 9 ›› Issue (6): 1085-1089.

• 反应与分离 • 上一篇    下一篇

含铁模拟酶催化苯羟基化反应

周仕林 邹峰 顾颖颖   

  1. 上海理工大学理学院 上海理工大学理学院 上海理工大学理学院
  • 收稿日期:2009-06-05 修回日期:2009-08-31 出版日期:2009-12-20 发布日期:2009-12-20
  • 通讯作者: 顾颖颖

Hydroxylation of Benzene by Mimetic Enzyme of Iron Complexes

ZHOU Shi-lin ZOU Feng GU Ying-ying   

  1. University of Shanghai for Science and Technology, College of Science University of Shanghai for Science and Technology, College of Science University of Shanghai for Science and Technology, College of Science
  • Received:2009-06-05 Revised:2009-08-31 Online:2009-12-20 Published:2009-12-20
  • Contact: GU Ying-ying

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摘要： 对比测试了多种含铁模拟酶对苯羟基化反应的催化性能，发现能同时提供氮和氧配位原子的乙二胺四乙酸([FeIII(EDTA)]-)表现出非常高的催化活性. 以分子氧为氧化剂，抗坏血酸为还原剂，在[FeIII(EDTA)]-的催化下，苯酚的产率和选择性分别达到了15.8%和100%. 考察了氧气压力、反应温度和反应时间对反应的影响，并对其动力学和机理进行了初步探讨. 氧气和苯对该反应均为一级反应. [FeIII(EDTA)]-在还原剂的作用下，能将分子氧活化为羟基自由基与苯进行羟基化反应.

关键词: 乙二胺四乙酸铁, 模拟酶, 苯, 苯酚, 氧化, 羟基化

Abstract: The mimetic enzymes of iron complexes were found to be very good catalysts for one-step benzene hydroxylation to phenol. [FeIII(EDTA)]- performed the most excellent catalytic activity among the mimetic enzyme catalysts tested in this work. Molecular oxygen and ascorbic acid were used as oxidant and reductant, respectively, in this reaction. The phenol yield and selectivity were obtained as high as 15.8% and 100%, respectively. The effects of some reaction conditions, such as oxygen pressure, reaction temperature and time, on the benzene hydroxylation were investigated. And the kinetics and mechanism of benzene hydroxylation were also studied. In the presence of reducing agent, molecular oxygen could be activated to hydroxyl radical over [FeIII(EDTA)]-.

Key words: [FeII(EDTA)], mimetic enzyme, benzene, phenol, oxidation, hydroxylation

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